DBCO-PEG3-oxyamine

Name: DBCO-PEG3-oxyamine
Brand: MedChemExpress
SKU: HY-133429
Rating: 4.5 (1 reviews)

Cat. No.: HY-133429 Purity: 98.05%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DBCO-PEG3-oxyamine is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG3-oxyamine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG3-oxyamine Chemical Structure

CAS No. : 2748394-67-2

Size	Price	Stock	Quantity
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

DBCO-PEG3-oxyamine is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. DBCO-PEG3-oxyamine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Non-cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

552.62

Formula

C₂₉H₃₆N₄O₇

CAS No.

2748394-67-2

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCNC(CON)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (180.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8096 mL	9.0478 mL	18.0956 mL
5 mM	0.3619 mL	1.8096 mL	3.6191 mL
10 mM	0.1810 mL	0.9048 mL	1.8096 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.05%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (242 KB) HNMR (123 KB) RP-HPLC (140 KB) LCMS (354 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8096 mL	9.0478 mL	18.0956 mL	45.2390 mL
	5 mM	0.3619 mL	1.8096 mL	3.6191 mL	9.0478 mL
	10 mM	0.1810 mL	0.9048 mL	1.8096 mL	4.5239 mL
	15 mM	0.1206 mL	0.6032 mL	1.2064 mL	3.0159 mL
	20 mM	0.0905 mL	0.4524 mL	0.9048 mL	2.2620 mL
	25 mM	0.0724 mL	0.3619 mL	0.7238 mL	1.8096 mL
	30 mM	0.0603 mL	0.3016 mL	0.6032 mL	1.5080 mL
	40 mM	0.0452 mL	0.2262 mL	0.4524 mL	1.1310 mL
	50 mM	0.0362 mL	0.1810 mL	0.3619 mL	0.9048 mL
	60 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7540 mL
	80 mM	0.0226 mL	0.1131 mL	0.2262 mL	0.5655 mL
	100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.4524 mL