TCO-PEG1-Val-Cit-PABC-PNP TFA

Cat. No.: HY-136100A Pureza: 99.69%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

TCO-PEG1-Val-Cit-PABC-PNP TFA is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG1-Val-Cit-PABC-PNP TFA is a click chemistry reagent, which contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

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TCO-PEG1-Val-Cit-PABC-PNP TFA Estructura química

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of TCO-PEG1-Val-Cit-PABC-PNP TFA:

TCO-PEG1-Val-Cit-PABC-PNP Obtener un presupuesto

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas ADC Linker:

Ver todas las isoformas

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target^[1]

Cleavable Linker

Protease Cleavable Linker

Peso molecular

925.90

Fòrmula

C₄₁H₅₄F₃N₇O₁₄

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1/C=C/CCCCC1)NCCOCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC(OC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCNC(N)=O)=O)C(C)C)=O.O=C(C(F)(F)F)O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (108.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0800 mL	5.4002 mL	10.8003 mL
5 mM	0.2160 mL	1.0800 mL	2.1601 mL
10 mM	0.1080 mL	0.5400 mL	1.0800 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.69%

Select Batch:

Ficha de datos (271 KB) SDS (252 KB)

COA (250 KB) HNMR (361 KB) LCMS (106 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0800 mL	5.4002 mL	10.8003 mL	27.0008 mL
	5 mM	0.2160 mL	1.0800 mL	2.1601 mL	5.4002 mL
	10 mM	0.1080 mL	0.5400 mL	1.0800 mL	2.7001 mL
	15 mM	0.0720 mL	0.3600 mL	0.7200 mL	1.8001 mL
	20 mM	0.0540 mL	0.2700 mL	0.5400 mL	1.3500 mL
	25 mM	0.0432 mL	0.2160 mL	0.4320 mL	1.0800 mL
	30 mM	0.0360 mL	0.1800 mL	0.3600 mL	0.9000 mL
	40 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6750 mL
	50 mM	0.0216 mL	0.1080 mL	0.2160 mL	0.5400 mL
	60 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.4500 mL
	80 mM	0.0135 mL	0.0675 mL	0.1350 mL	0.3375 mL
	100 mM	0.0108 mL	0.0540 mL	0.1080 mL	0.2700 mL