TCO-PEG1-Val-Cit-PABC-PNP TFA
Based on 1 Customer Validation
TCO-PEG1-Val-Cit-PABC-PNP TFA is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG1-Val-Cit-PABC-PNP TFA is a click chemistry reagent, which contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
For research use only. We do not sell to patients.
- Purity : 99.69%
- Formula: C41H54F3N7O14
- Molecular Weight:925.90
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Cleavable Linker |
Protease Cleavable Linker |
Chemical Information
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Appearance Solid
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Molecular Weight 925.90
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Formula C41H54F3N7O14
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Color White to off-white
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SMILES
O=C(OC1/C=C/CCCCC1)NCCOCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC(OC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCNC(N)=O)=O)C(C)C)=O.O=C(C(F)(F)F)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (108.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0800 mL | 5.4002 mL | 10.8003 mL | 27.0008 mL |
| 5 mM | 0.2160 mL | 1.0800 mL | 2.1601 mL | 5.4002 mL | |
| 10 mM | 0.1080 mL | 0.5400 mL | 1.0800 mL | 2.7001 mL | |
| 15 mM | 0.0720 mL | 0.3600 mL | 0.7200 mL | 1.8001 mL | |
| 20 mM | 0.0540 mL | 0.2700 mL | 0.5400 mL | 1.3500 mL | |
| 25 mM | 0.0432 mL | 0.2160 mL | 0.4320 mL | 1.0800 mL | |
| 30 mM | 0.0360 mL | 0.1800 mL | 0.3600 mL | 0.9000 mL | |
| 40 mM | 0.0270 mL | 0.1350 mL | 0.2700 mL | 0.6750 mL | |
| 50 mM | 0.0216 mL | 0.1080 mL | 0.2160 mL | 0.5400 mL | |
| 60 mM | 0.0180 mL | 0.0900 mL | 0.1800 mL | 0.4500 mL | |
| 80 mM | 0.0135 mL | 0.0675 mL | 0.1350 mL | 0.3375 mL | |
| 100 mM | 0.0108 mL | 0.0540 mL | 0.1080 mL | 0.2700 mL |
TCO-PEG1-Val-Cit-PABC-PNP TFA Related Classifications
HY-136100A Related Classifications
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