TCO-PEG1-Val-Cit-PABC-PNP TFA

Cat. No.: HY-136100A Purity: 99.69%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

TCO-PEG1-Val-Cit-PABC-PNP TFA is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG1-Val-Cit-PABC-PNP TFA is a click chemistry reagent, which contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

TCO-PEG1-Val-Cit-PABC-PNP TFA 화학구조

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of TCO-PEG1-Val-Cit-PABC-PNP TFA:

TCO-PEG1-Val-Cit-PABC-PNP 견적 받기

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

Cleavable Linker

Protease Cleavable Linker

분자량

925.90

화학식

C₄₁H₅₄F₃N₇O₁₄

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1/C=C/CCCCC1)NCCOCCC(N[C@H](C(N[C@H](C(NC2=CC=C(C=C2)COC(OC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCNC(N)=O)=O)C(C)C)=O.O=C(C(F)(F)F)O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (108.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0800 mL	5.4002 mL	10.8003 mL
5 mM	0.2160 mL	1.0800 mL	2.1601 mL
10 mM	0.1080 mL	0.5400 mL	1.0800 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.69%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (250 KB) HNMR (361 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0800 mL	5.4002 mL	10.8003 mL	27.0008 mL
	5 mM	0.2160 mL	1.0800 mL	2.1601 mL	5.4002 mL
	10 mM	0.1080 mL	0.5400 mL	1.0800 mL	2.7001 mL
	15 mM	0.0720 mL	0.3600 mL	0.7200 mL	1.8001 mL
	20 mM	0.0540 mL	0.2700 mL	0.5400 mL	1.3500 mL
	25 mM	0.0432 mL	0.2160 mL	0.4320 mL	1.0800 mL
	30 mM	0.0360 mL	0.1800 mL	0.3600 mL	0.9000 mL
	40 mM	0.0270 mL	0.1350 mL	0.2700 mL	0.6750 mL
	50 mM	0.0216 mL	0.1080 mL	0.2160 mL	0.5400 mL
	60 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.4500 mL
	80 mM	0.0135 mL	0.0675 mL	0.1350 mL	0.3375 mL
	100 mM	0.0108 mL	0.0540 mL	0.1080 mL	0.2700 mL