NH2-C5-PEG4-N3-L-Lysine-PEG3-N3
Based on 1 Customer Validation
NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 98.59%
- CAS No.: 2739938-35-1
- Formula: C25H49N9O9
- Molecular Weight:619.71
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2739938-35-1
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Appearance Liquid
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Molecular Weight 619.71
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Formula C25H49N9O9
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Color Colorless to light yellow
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SMILES
O=C([C@H](CCCCN)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)NCCOCCOCCOCCN=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 83.33 mg/mL (134.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6137 mL | 8.0683 mL | 16.1366 mL | 40.3414 mL |
| 5 mM | 0.3227 mL | 1.6137 mL | 3.2273 mL | 8.0683 mL | |
| 10 mM | 0.1614 mL | 0.8068 mL | 1.6137 mL | 4.0341 mL | |
| 15 mM | 0.1076 mL | 0.5379 mL | 1.0758 mL | 2.6894 mL | |
| 20 mM | 0.0807 mL | 0.4034 mL | 0.8068 mL | 2.0171 mL | |
| 25 mM | 0.0645 mL | 0.3227 mL | 0.6455 mL | 1.6137 mL | |
| 30 mM | 0.0538 mL | 0.2689 mL | 0.5379 mL | 1.3447 mL | |
| 40 mM | 0.0403 mL | 0.2017 mL | 0.4034 mL | 1.0085 mL | |
| 50 mM | 0.0323 mL | 0.1614 mL | 0.3227 mL | 0.8068 mL | |
| 60 mM | 0.0269 mL | 0.1345 mL | 0.2689 mL | 0.6724 mL | |
| 80 mM | 0.0202 mL | 0.1009 mL | 0.2017 mL | 0.5043 mL | |
| 100 mM | 0.0161 mL | 0.0807 mL | 0.1614 mL | 0.4034 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 Related Classifications
HY-130946 Related Classifications
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