Fmoc-Val-Ala-PAB-PNP

Name: Fmoc-Val-Ala-PAB-PNP
Brand: MedChemExpress
SKU: HY-136136
Rating: 4.5 (1 reviews)

Cat. No.: HY-136136 Purity: 98.06%: FAQs
Data Sheet SDS COA Handling Instructions

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Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Val-Ala-PAB-PNP Chemical Structure

CAS No. : 1394238-92-6

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Free Sample (0.1 - 0.5 mg)		Apply Now
100 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
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1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

680.70

Formula

C₃₇H₃₆N₄O₉

CAS No.

1394238-92-6

Appearance

Solid

Color

White to light yellow

SMILES

[O-][N+](C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](C)NC([C@H](C(C)C)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (146.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4691 mL	7.3454 mL	14.6908 mL
5 mM	0.2938 mL	1.4691 mL	2.9382 mL
10 mM	0.1469 mL	0.7345 mL	1.4691 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.06%

Select Batch:

Data Sheet (269 KB) SDS (0 KB)

COA (246 KB) HNMR (310 KB) RP-HPLC (246 KB) MS (74 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4691 mL	7.3454 mL	14.6908 mL	36.7269 mL
	5 mM	0.2938 mL	1.4691 mL	2.9382 mL	7.3454 mL
	10 mM	0.1469 mL	0.7345 mL	1.4691 mL	3.6727 mL
	15 mM	0.0979 mL	0.4897 mL	0.9794 mL	2.4485 mL
	20 mM	0.0735 mL	0.3673 mL	0.7345 mL	1.8363 mL
	25 mM	0.0588 mL	0.2938 mL	0.5876 mL	1.4691 mL
	30 mM	0.0490 mL	0.2448 mL	0.4897 mL	1.2242 mL
	40 mM	0.0367 mL	0.1836 mL	0.3673 mL	0.9182 mL
	50 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7345 mL
	60 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.6121 mL
	80 mM	0.0184 mL	0.0918 mL	0.1836 mL	0.4591 mL
	100 mM	0.0147 mL	0.0735 mL	0.1469 mL	0.3673 mL