Fmoc-Val-Ala-PAB-PNP
Based on 1 Customer Validation
Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 99.28%
- CAS No.: 1394238-92-6
- Formula: C37H36N4O9
- Molecular Weight:680.70
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1394238-92-6
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Appearance Solid
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Molecular Weight 680.70
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Formula C37H36N4O9
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Color White to light yellow
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SMILES
[O-][N+](C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](C)NC([C@H](C(C)C)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (146.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4691 mL | 7.3454 mL | 14.6908 mL | 36.7269 mL |
| 5 mM | 0.2938 mL | 1.4691 mL | 2.9382 mL | 7.3454 mL | |
| 10 mM | 0.1469 mL | 0.7345 mL | 1.4691 mL | 3.6727 mL | |
| 15 mM | 0.0979 mL | 0.4897 mL | 0.9794 mL | 2.4485 mL | |
| 20 mM | 0.0735 mL | 0.3673 mL | 0.7345 mL | 1.8363 mL | |
| 25 mM | 0.0588 mL | 0.2938 mL | 0.5876 mL | 1.4691 mL | |
| 30 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL | |
| 40 mM | 0.0367 mL | 0.1836 mL | 0.3673 mL | 0.9182 mL | |
| 50 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7345 mL | |
| 60 mM | 0.0245 mL | 0.1224 mL | 0.2448 mL | 0.6121 mL | |
| 80 mM | 0.0184 mL | 0.0918 mL | 0.1836 mL | 0.4591 mL | |
| 100 mM | 0.0147 mL | 0.0735 mL | 0.1469 mL | 0.3673 mL |
Fmoc-Val-Ala-PAB-PNP Related Classifications
HY-136136 Related Classifications
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