2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mc-Gly-Gly-Phe-Gly-PAB-OH

Mc-Gly-Gly-Phe-Gly-PAB-OH  (Synonyms: Mc-GGFG-PAB-OH)

Cat. No.: HY-136432 Purity: 98.03%
COA Handling Instructions

Molarity Calculator

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Mc-Gly-Gly-Phe-Gly-PAB-OH Chemical Structure

Mc-Gly-Gly-Phe-Gly-PAB-OH Chemical Structure

CAS No. : 2632342-05-1

Size Price Stock Quantity
5 mg USD 94 In-stock
10 mg USD 150 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Mc-Gly-Gly-Phe-Gly-PAB-OH:

Mc-Gly-Gly-Phe-Gly-PAB-OH Related Antibodies

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Description

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

IC50 & Target[1]

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mc-Gly-Gly-Phe-Gly-PAB-OH Related Antibodies
Molecular Weight

634.68

Formula

C32H38N6O8
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (393.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5756 mL 7.8780 mL 15.7560 mL
5 mM 0.3151 mL 1.5756 mL 3.1512 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.03%

COA (243 KB) HNMR (313 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5756 mL 7.8780 mL 15.7560 mL 39.3899 mL
5 mM 0.3151 mL 1.5756 mL 3.1512 mL 7.8780 mL
10 mM 0.1576 mL 0.7878 mL 1.5756 mL 3.9390 mL
15 mM 0.1050 mL 0.5252 mL 1.0504 mL 2.6260 mL
20 mM 0.0788 mL 0.3939 mL 0.7878 mL 1.9695 mL
25 mM 0.0630 mL 0.3151 mL 0.6302 mL 1.5756 mL
30 mM 0.0525 mL 0.2626 mL 0.5252 mL 1.3130 mL
40 mM 0.0394 mL 0.1969 mL 0.3939 mL 0.9847 mL
50 mM 0.0315 mL 0.1576 mL 0.3151 mL 0.7878 mL
60 mM 0.0263 mL 0.1313 mL 0.2626 mL 0.6565 mL
80 mM 0.0197 mL 0.0985 mL 0.1969 mL 0.4924 mL
100 mM 0.0158 mL 0.0788 mL 0.1576 mL 0.3939 mL
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Mc-Gly-Gly-Phe-Gly-PAB-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mc-Gly-Gly-Phe-Gly-PAB-OH2632342-05-1Mc-GGFG-PAB-OHADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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