1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. DBCO-CONH-S-S-NHS ester

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-CONH-S-S-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-CONH-S-S-NHS ester Chemical Structure

DBCO-CONH-S-S-NHS ester Chemical Structure

CAS No. : 1435934-53-4

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5 mg USD 200 In-stock
10 mg USD 325 In-stock
25 mg USD 650 In-stock
50 mg USD 950 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DBCO-CONH-S-S-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-CONH-S-S-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

565.66

Formula

C28H27N3O6S2

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCSSCCC(ON4C(CCC4=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (176.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7678 mL 8.8392 mL 17.6785 mL
5 mM 0.3536 mL 1.7678 mL 3.5357 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.07%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7678 mL 8.8392 mL 17.6785 mL 44.1962 mL
5 mM 0.3536 mL 1.7678 mL 3.5357 mL 8.8392 mL
10 mM 0.1768 mL 0.8839 mL 1.7678 mL 4.4196 mL
15 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9464 mL
20 mM 0.0884 mL 0.4420 mL 0.8839 mL 2.2098 mL
25 mM 0.0707 mL 0.3536 mL 0.7071 mL 1.7678 mL
30 mM 0.0589 mL 0.2946 mL 0.5893 mL 1.4732 mL
40 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1049 mL
50 mM 0.0354 mL 0.1768 mL 0.3536 mL 0.8839 mL
60 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7366 mL
80 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5525 mL
100 mM 0.0177 mL 0.0884 mL 0.1768 mL 0.4420 mL
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DBCO-CONH-S-S-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DBCO-CONH-S-S-NHS ester
Cat. No.:
HY-133413
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