TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride

Name: TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride
Brand: MedChemExpress
SKU: HY-156691A
Rating: 4.5 (1 reviews)

Cat. No.: HY-156691A: FAQs
Data Sheet Handling Instructions

Molarity Calculator

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is a Drug-Linker Conjugates for ADC. TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride is the hydrochloride form of TLR7/8 agonist 4 hydroxy-PEG6-acid. TLR7/8 agonist 4 hydroxy-PEG6-acid consists of TLR7/8 agonist 4 (HY-139017) and a linker Hydroxy-PEG6-acid (HY-133050), and can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1900	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride:

TLR7/8 agonist 4 hydroxy-PEG6-acid Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

697.26

Formula

C₃₃H₅₃ClN₆O₈

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCOCCOCCOCCOCCOCCOCCN1CCN(CC1)C2=CC3=C(N=C(C4=C3NC(CCCC)=N4)N)C=C2)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (71.71 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4342 mL	7.1709 mL	14.3419 mL
5 mM	0.2868 mL	1.4342 mL	2.8684 mL
10 mM	0.1434 mL	0.7171 mL	1.4342 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shelley Erin ACKERMAN, et al. Macromolecule-supported tlr agonists. Patent. WO2020190762A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4342 mL	7.1709 mL	14.3419 mL	35.8546 mL
	5 mM	0.2868 mL	1.4342 mL	2.8684 mL	7.1709 mL
	10 mM	0.1434 mL	0.7171 mL	1.4342 mL	3.5855 mL
	15 mM	0.0956 mL	0.4781 mL	0.9561 mL	2.3903 mL
	20 mM	0.0717 mL	0.3585 mL	0.7171 mL	1.7927 mL
	25 mM	0.0574 mL	0.2868 mL	0.5737 mL	1.4342 mL
	30 mM	0.0478 mL	0.2390 mL	0.4781 mL	1.1952 mL
	40 mM	0.0359 mL	0.1793 mL	0.3585 mL	0.8964 mL
	50 mM	0.0287 mL	0.1434 mL	0.2868 mL	0.7171 mL
	60 mM	0.0239 mL	0.1195 mL	0.2390 mL	0.5976 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.