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Cat. No.: HY-W109224

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3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid

Name: 3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid
Brand: MedChemExpress
SKU: HY-W109224
Price: 55.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid is a ROS-sensitive cleavable linker. 3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid is stable under physiological conditions, but undergoes cleavage in the ROS-rich tumor microenvironment, enabling the release of conjugated Camptothecin (CPT) (HY-16560). 3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid can be used in the research of cervical cancer.

For research use only. We do not sell to patients.

Purity: 97.0%
CAS No.: 4265-59-2
Formula: C₉H₁₆O₄S₂
Molecular Weight:252.35

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid Chemical Structure

CAS No.: 4265-59-2

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Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

All ADC Linkers Isoforms :

In Vitro

3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid (72 h) is a ROS-sensitive linker in TK-CPT-PMPSD nanoparticles. In the presence of 10 μM and 25 μM H₂O₂, it releases 63% and 80% of the conjugated CPT within 72 hours, respectively, while remains stable under physiological conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 4265-59-2
Appearance Solid
Molecular Weight 252.35
Formula C₉H₁₆O₄S₂
Color White to off-white
SMILES

CC(SCCC(O)=O)(SCCC(O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mathew, J., Le, T. N., Pham, H. P., Kumar, P., Lee, C. K., Shunmugam, R., & Rao, N. V. (2024). ROS-responsive camptothecin-linked thioketal drug delivery system based on ring-closing polymerization. European Polymer Journal, 202, 112646.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid

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3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid

All ADC Linkers Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid Related Classifications

HY-W109224 Related Classifications

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