3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid
Based on 1 Customer Validation
3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid is a ROS-sensitive cleavable linker. 3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid is stable under physiological conditions, but undergoes cleavage in the ROS-rich tumor microenvironment, enabling the release of conjugated Camptothecin (CPT) (HY-16560). 3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid can be used in the research of cervical cancer.
For research use only. We do not sell to patients.
- Purity : 97.0%
- CAS No.: 4265-59-2
- Formula: C9H16O4S2
- Molecular Weight:252.35
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
3,3'-(Propane-2,2-diylbis (sulfanediyl)) dipropionic acid (72 h) is a ROS-sensitive linker in TK-CPT-PMPSD nanoparticles. In the presence of 10 μM and 25 μM H2O2, it releases 63% and 80% of the conjugated CPT within 72 hours, respectively, while remains stable under physiological conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4265-59-2
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Appearance Solid
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Molecular Weight 252.35
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Formula C9H16O4S2
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Color White to off-white
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SMILES
CC(SCCC(O)=O)(SCCC(O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (396.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9628 mL | 19.8138 mL | 39.6275 mL | 99.0688 mL |
| 5 mM | 0.7926 mL | 3.9628 mL | 7.9255 mL | 19.8138 mL | |
| 10 mM | 0.3963 mL | 1.9814 mL | 3.9628 mL | 9.9069 mL | |
| 15 mM | 0.2642 mL | 1.3209 mL | 2.6418 mL | 6.6046 mL | |
| 20 mM | 0.1981 mL | 0.9907 mL | 1.9814 mL | 4.9534 mL | |
| 25 mM | 0.1585 mL | 0.7926 mL | 1.5851 mL | 3.9628 mL | |
| 30 mM | 0.1321 mL | 0.6605 mL | 1.3209 mL | 3.3023 mL | |
| 40 mM | 0.0991 mL | 0.4953 mL | 0.9907 mL | 2.4767 mL | |
| 50 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9814 mL | |
| 60 mM | 0.0660 mL | 0.3302 mL | 0.6605 mL | 1.6511 mL | |
| 80 mM | 0.0495 mL | 0.2477 mL | 0.4953 mL | 1.2384 mL | |
| 100 mM | 0.0396 mL | 0.1981 mL | 0.3963 mL | 0.9907 mL |
3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid Related Classifications
HY-W109224 Related Classifications
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Keywords
- 3,3'-(Propane-2,2-diylbis(sulfanediyl))dipropionic acid
- 4265-59-2
- ADC Linkers
- Reactive Oxygen Species (ROS)
- camptothecin
- 1H NMR spectroscopy
- L929 normal cells
- HeLa cancer cell
- reactive oxygen species
- endocytic uptake
- Steglich esterification
- tumor microenvironments
- FTIR spectroscopy
- uterine cervical cancer
- Inhibitor
- inhibitor
- inhibit