1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Boc-Val-Dil-Dap-OH

Boc-Val-Dil-Dap-OH 

Cat. No.: HY-130961 Purity: 99.86%
Handling Instructions

Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Boc-Val-Dil-Dap-OH Chemical Structure

Boc-Val-Dil-Dap-OH Chemical Structure

Size Price Stock Quantity
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Boc-Val-Dil-Dap-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

571.75

Formula

C₂₉H₅₃N₃O₈

SMILES

CC([[email protected]](NC(OC(C)(C)C)=O)C(N([[email protected]]([[email protected]@H](CC(N1[[email protected]@H](CCC1)[[email protected]@H]([[email protected]](C(O)=O)C)OC)=O)OC)[[email protected]](CC)C)C)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7490 mL 8.7451 mL 17.4902 mL
5 mM 0.3498 mL 1.7490 mL 3.4980 mL
10 mM 0.1749 mL 0.8745 mL 1.7490 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.86%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Boc-Val-Dil-Dap-OHADC LinkerAntibody-drug conjugates linkernon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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Product Name:
Boc-Val-Dil-Dap-OH
Cat. No.:
HY-130961
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