Tetrazine-SS-PEG4-Biotin
Based on 1 Customer Validation
Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
For research use only. We do not sell to patients.
- Purity: 99.42%
- Formula: C35H53N9O8S3
- Molecular Weight:824.05
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Disulfide Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 824.05
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Formula C35H53N9O8S3
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Color Purple to purplish red
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SMILES
O=C(CCSSCCNC(CCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)=O)NCC(C=C3)=CC=C3C4=NN=CN=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (60.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2135 mL | 6.0676 mL | 12.1352 mL | 30.3380 mL |
| 5 mM | 0.2427 mL | 1.2135 mL | 2.4270 mL | 6.0676 mL | |
| 10 mM | 0.1214 mL | 0.6068 mL | 1.2135 mL | 3.0338 mL | |
| 15 mM | 0.0809 mL | 0.4045 mL | 0.8090 mL | 2.0225 mL | |
| 20 mM | 0.0607 mL | 0.3034 mL | 0.6068 mL | 1.5169 mL | |
| 25 mM | 0.0485 mL | 0.2427 mL | 0.4854 mL | 1.2135 mL | |
| 30 mM | 0.0405 mL | 0.2023 mL | 0.4045 mL | 1.0113 mL | |
| 40 mM | 0.0303 mL | 0.1517 mL | 0.3034 mL | 0.7584 mL | |
| 50 mM | 0.0243 mL | 0.1214 mL | 0.2427 mL | 0.6068 mL | |
| 60 mM | 0.0202 mL | 0.1011 mL | 0.2023 mL | 0.5056 mL |
Tetrazine-SS-PEG4-Biotin Related Classifications
HY-136036 Related Classifications
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