DBCO-PEG4-acetic-Val-Cit-PAB
Based on 1 Customer Validation
DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-acetic-Val-Cit-PAB is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.23%
- Formula: C45H57N7O10
- Molecular Weight:855.97
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 855.97
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Formula C45H57N7O10
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Color Off-white to yellow
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SMILES
O=C(CCC(NCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)=O)=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (116.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1683 mL | 5.8413 mL | 11.6827 mL | 29.2066 mL |
| 5 mM | 0.2337 mL | 1.1683 mL | 2.3365 mL | 5.8413 mL | |
| 10 mM | 0.1168 mL | 0.5841 mL | 1.1683 mL | 2.9207 mL | |
| 15 mM | 0.0779 mL | 0.3894 mL | 0.7788 mL | 1.9471 mL | |
| 20 mM | 0.0584 mL | 0.2921 mL | 0.5841 mL | 1.4603 mL | |
| 25 mM | 0.0467 mL | 0.2337 mL | 0.4673 mL | 1.1683 mL | |
| 30 mM | 0.0389 mL | 0.1947 mL | 0.3894 mL | 0.9736 mL | |
| 40 mM | 0.0292 mL | 0.1460 mL | 0.2921 mL | 0.7302 mL | |
| 50 mM | 0.0234 mL | 0.1168 mL | 0.2337 mL | 0.5841 mL | |
| 60 mM | 0.0195 mL | 0.0974 mL | 0.1947 mL | 0.4868 mL | |
| 80 mM | 0.0146 mL | 0.0730 mL | 0.1460 mL | 0.3651 mL | |
| 100 mM | 0.0117 mL | 0.0584 mL | 0.1168 mL | 0.2921 mL |
DBCO-PEG4-acetic-Val-Cit-PAB Related Classifications
HY-136098 Related Classifications
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