DBCO-PEG4-acetic-Val-Cit-PAB

Name: DBCO-PEG4-acetic-Val-Cit-PAB
Brand: MedChemExpress
SKU: HY-136098
Rating: 4.5 (1 reviews)

Cat. No.: HY-136098 Purity: 98.21%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-acetic-Val-Cit-PAB is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG4-acetic-Val-Cit-PAB Chemical Structure

Size	Price	Stock	Quantity
50 mg	USD 999	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1700	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DBCO-PEG4-acetic-Val-Cit-PAB is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. DBCO-PEG4-acetic-Val-Cit-PAB is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

855.97

Formula

C₄₅H₅₇N₇O₁₀

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(CCC(NCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)=O)=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (116.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1683 mL	5.8413 mL	11.6827 mL
5 mM	0.2337 mL	1.1683 mL	2.3365 mL
10 mM	0.1168 mL	0.5841 mL	1.1683 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.21%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (394 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1683 mL	5.8413 mL	11.6827 mL	29.2066 mL
	5 mM	0.2337 mL	1.1683 mL	2.3365 mL	5.8413 mL
	10 mM	0.1168 mL	0.5841 mL	1.1683 mL	2.9207 mL
	15 mM	0.0779 mL	0.3894 mL	0.7788 mL	1.9471 mL
	20 mM	0.0584 mL	0.2921 mL	0.5841 mL	1.4603 mL
	25 mM	0.0467 mL	0.2337 mL	0.4673 mL	1.1683 mL
	30 mM	0.0389 mL	0.1947 mL	0.3894 mL	0.9736 mL
	40 mM	0.0292 mL	0.1460 mL	0.2921 mL	0.7302 mL
	50 mM	0.0234 mL	0.1168 mL	0.2337 mL	0.5841 mL
	60 mM	0.0195 mL	0.0974 mL	0.1947 mL	0.4868 mL
	80 mM	0.0146 mL	0.0730 mL	0.1460 mL	0.3651 mL
	100 mM	0.0117 mL	0.0584 mL	0.1168 mL	0.2921 mL