2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. N-(5-Hydroxypentyl)maleimide

N-(5-Hydroxypentyl)maleimide 

Cat. No.: HY-130818 Purity: 99.89%
COA Handling Instructions

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) ).

For research use only. We do not sell to patients.

N-(5-Hydroxypentyl)maleimide Chemical Structure

N-(5-Hydroxypentyl)maleimide Chemical Structure

CAS No. : 180608-78-0

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Description

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].

IC50 & Target[1]

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

183.20

Appearance

Oil

Formula

C9H13NO3
CAS No.
SMILES

OCCCCCN1C(C=CC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

N-(5-Hydroxypentyl)maleimide180608-78-0ADC LinkerAntibody-drug conjugates linkerADCnon-cleavablelinkerInhibitorinhibitorinhibit

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