1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Gemcitabine-O-Si(di-iso)-O-Mc

Gemcitabine-O-Si(di-iso)-O-Mc 

Cat. No.: HY-130812
Handling Instructions

Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker.

For research use only. We do not sell to patients.

Gemcitabine-O-Si(di-iso)-O-Mc Chemical Structure

Gemcitabine-O-Si(di-iso)-O-Mc Chemical Structure

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Description

Gemcitabine-O-Si(di-iso)-O-Mc is a drug-linker conjugate for ADC with potent antitumor activity by using Gemcitabine (a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent; HY-17026), linked via the ADC linker[1].

In Vitro

Antibody drug conjugates (ADC) couple therapeutic monoclonal antibodies (mAb) with potent toxins through a linker that is stable within systemic circulation, but cleaves within the target cells[1].

Molecular Weight

558.65

Formula

C₂₄H₃₆F₂N₄O₇Si

SMILES

NC(C=CN1[[email protected]]2C(F)([[email protected]@H]([[email protected]](O2)CO[Si](C(C)C)(OCCCCCN3C(C=CC3=O)=O)C(C)C)O)F)=NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Gemcitabine-O-Si(di-iso)-O-McDrug-Linker Conjugates for ADCcleavableADCantibody-drugconjugatesGemcitabinepyrimidinenucleosideanalogantimetaboliteantineoplasticInhibitorinhibitorinhibit

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Product name:
Gemcitabine-O-Si(di-iso)-O-Mc
Cat. No.:
HY-130812
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