BCN-PEG1-Val-Cit-PABC-OH
Based on 1 Customer Validation
BCN-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BCN-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 95.0%
- Formula: C34H50N6O8
- Molecular Weight:670.80
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Protease Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 670.80
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Formula C34H50N6O8
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Color White to off-white
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SMILES
O=C(NCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)=O)OCC2[C@]3([H])[C@@]2([H])CCC#CCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (149.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4908 mL | 7.4538 mL | 14.9076 mL | 37.2689 mL |
| 5 mM | 0.2982 mL | 1.4908 mL | 2.9815 mL | 7.4538 mL | |
| 10 mM | 0.1491 mL | 0.7454 mL | 1.4908 mL | 3.7269 mL | |
| 15 mM | 0.0994 mL | 0.4969 mL | 0.9938 mL | 2.4846 mL | |
| 20 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8634 mL | |
| 25 mM | 0.0596 mL | 0.2982 mL | 0.5963 mL | 1.4908 mL | |
| 30 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL | 1.2423 mL | |
| 40 mM | 0.0373 mL | 0.1863 mL | 0.3727 mL | 0.9317 mL | |
| 50 mM | 0.0298 mL | 0.1491 mL | 0.2982 mL | 0.7454 mL | |
| 60 mM | 0.0248 mL | 0.1242 mL | 0.2485 mL | 0.6211 mL | |
| 80 mM | 0.0186 mL | 0.0932 mL | 0.1863 mL | 0.4659 mL | |
| 100 mM | 0.0149 mL | 0.0745 mL | 0.1491 mL | 0.3727 mL |
BCN-PEG1-Val-Cit-PABC-OH Related Classifications
HY-130923 Related Classifications
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