Propargyl-PEG3-acid
Based on 1 Customer Validation
Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- Reinheit: 99.14%
- CAS. Nr.: 1347760-82-0
- Formel: C10H16O5
- Molecular Weight:216.23
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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PEGs |
Non-cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1347760-82-0
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Appearance Liquid (Density: 1.131±0.06 g/cm3)
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Molecular Weight 216.23
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Formel C10H16O5
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Color Colorless to light yellow
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SMILES
O=C(O)CCOCCOCCOCC#C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (462.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6247 mL | 23.1235 mL | 46.2471 mL | 115.6176 mL |
| 5 mM | 0.9249 mL | 4.6247 mL | 9.2494 mL | 23.1235 mL | |
| 10 mM | 0.4625 mL | 2.3124 mL | 4.6247 mL | 11.5618 mL | |
| 15 mM | 0.3083 mL | 1.5416 mL | 3.0831 mL | 7.7078 mL | |
| 20 mM | 0.2312 mL | 1.1562 mL | 2.3124 mL | 5.7809 mL | |
| 25 mM | 0.1850 mL | 0.9249 mL | 1.8499 mL | 4.6247 mL | |
| 30 mM | 0.1542 mL | 0.7708 mL | 1.5416 mL | 3.8539 mL | |
| 40 mM | 0.1156 mL | 0.5781 mL | 1.1562 mL | 2.8904 mL | |
| 50 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 2.3124 mL | |
| 60 mM | 0.0771 mL | 0.3854 mL | 0.7708 mL | 1.9270 mL | |
| 80 mM | 0.0578 mL | 0.2890 mL | 0.5781 mL | 1.4452 mL | |
| 100 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 1.1562 mL |
Propargyl-PEG3-acid Related Classifications
HY-126975 Related Classifications
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