Propargyl-PEG3-acid

Name: Propargyl-PEG3-acid
Brand: MedChemExpress
SKU: HY-126975
Rating: 4.5 (1 reviews)

Cat. No.: HY-126975 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG3-acid Chemical Structure

CAS No. : 1347760-82-0

Size	Price	Stock	Quantity
100 mg	USD 28	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 101	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid^[1]. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs	Non-cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

216.23

Formula

C₁₀H₁₆O₅

CAS No.

1347760-82-0

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (462.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6247 mL	23.1235 mL	46.2471 mL
5 mM	0.9249 mL	4.6247 mL	9.2494 mL
10 mM	0.4625 mL	2.3124 mL	4.6247 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (241 KB) HNMR (236 KB) MS (186 KB)

Handling Instructions (2659 KB)

References

[1]. Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377. [Content Brief]

[2]. Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6247 mL	23.1235 mL	46.2471 mL	115.6176 mL
	5 mM	0.9249 mL	4.6247 mL	9.2494 mL	23.1235 mL
	10 mM	0.4625 mL	2.3124 mL	4.6247 mL	11.5618 mL
	15 mM	0.3083 mL	1.5416 mL	3.0831 mL	7.7078 mL
	20 mM	0.2312 mL	1.1562 mL	2.3124 mL	5.7809 mL
	25 mM	0.1850 mL	0.9249 mL	1.8499 mL	4.6247 mL
	30 mM	0.1542 mL	0.7708 mL	1.5416 mL	3.8539 mL
	40 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8904 mL
	50 mM	0.0925 mL	0.4625 mL	0.9249 mL	2.3124 mL
	60 mM	0.0771 mL	0.3854 mL	0.7708 mL	1.9270 mL
	80 mM	0.0578 mL	0.2890 mL	0.5781 mL	1.4452 mL
	100 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL