Tetrazine-PEG7-amine hydrochloride

Name: Tetrazine-PEG7-amine hydrochloride
Brand: MedChemExpress
SKU: HY-148211
Rating: 4.5 (1 reviews)

Cat. No.: HY-148211 Purity: 99.16%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

For research use only. We do not sell to patients.

Tetrazine-PEG7-amine hydrochloride Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

603.11

Formula

C₂₆H₄₃ClN₆O₈

Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(CCOCCOCCOCCOCCOCCOCCOCCN)NCC(C=C1)=CC=C1C2=NN=CN=N2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (331.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6581 mL	8.2904 mL	16.5807 mL
5 mM	0.3316 mL	1.6581 mL	3.3161 mL
10 mM	0.1658 mL	0.8290 mL	1.6581 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.16%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (240 KB) HNMR (270 KB) LCMS (239 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et, al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6581 mL	8.2904 mL	16.5807 mL	41.4518 mL
	5 mM	0.3316 mL	1.6581 mL	3.3161 mL	8.2904 mL
	10 mM	0.1658 mL	0.8290 mL	1.6581 mL	4.1452 mL
	15 mM	0.1105 mL	0.5527 mL	1.1054 mL	2.7635 mL
	20 mM	0.0829 mL	0.4145 mL	0.8290 mL	2.0726 mL
	25 mM	0.0663 mL	0.3316 mL	0.6632 mL	1.6581 mL
	30 mM	0.0553 mL	0.2763 mL	0.5527 mL	1.3817 mL
	40 mM	0.0415 mL	0.2073 mL	0.4145 mL	1.0363 mL
	50 mM	0.0332 mL	0.1658 mL	0.3316 mL	0.8290 mL
	60 mM	0.0276 mL	0.1382 mL	0.2763 mL	0.6909 mL
	80 mM	0.0207 mL	0.1036 mL	0.2073 mL	0.5181 mL
	100 mM	0.0166 mL	0.0829 mL	0.1658 mL	0.4145 mL