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Cat. No.: HY-126676

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DBCO-(PEG2-Val-Cit-PAB)2

DBCO-(PEG2-Val-Cit-PAB)2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs). DBCO-(PEG2-Val-Cit-PAB)2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-(PEG2-Val-Cit-PAB)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Formula: C₆₉H₉₄N₁₂O₁₆
Molecular Weight:1347.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (245 KB)

DBCO-(PEG2-Val-Cit-PAB)2 Chemical Structure

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

Cleavable Linker

Protease Cleavable Linker

Alkyl/ether

PEGs

All ADC Linkers Isoforms :

All PROTAC Linkers Isoforms :

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1347.56
Formula C₆₉H₉₄N₁₂O₁₆
SMILES

OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN(CCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CO)C=C2)=O)=O)=O)C(CCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.