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Results for "

cancer+cell+lines

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) ADC Payload (5) Adenosine Receptor (2) Adrenergic Receptor (2) Akt (16) Aldehyde Dehydrogenase (ALDH) (2) AMPK (6) Amylases (1) Anaplastic lymphoma kinase (ALK) (4) Androgen Receptor (7) Antibiotic (3) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (196) Arenavirus (1) Aryl Hydrocarbon Receptor (2) Aurora Kinase (5) Autophagy (25) Bacterial (17) Bcl-2 Family (16) Bcr-Abl (1) BCRP (1) Biochemical Assay Reagents (10) c-Met/HGFR (7) c-Myc (2) Calcium Channel (3) Carbonic Anhydrase (3) Casein Kinase (1) Caspase (27) CD3 (1) CD38 (1) CD44 (3) CDK (19) Checkpoint Kinase (Chk) (3) Cholinesterase (ChE) (4) ClpP (1) COX (1) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (4) Dengue Virus (1) Deubiquitinase (2) Dihydrofolate reductase (DHFR) (2) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (3) DNA Methyltransferase (1) DNA-PK (2) DNA/RNA Synthesis (10) Dopamine Receptor (1) Drug Derivative (13) Drug Isomer (1) Drug Metabolite (2) Drug-Linker Conjugates for ADC (2) DYRK (3) EGFR (24) Endogenous Metabolite (21) Environmental Pollutants (5) Ephrin Receptor (1) Epigenetic Reader Domain (11) ERK (8) Estrogen Receptor/ERR (20) FAK (5) Farnesyl Transferase (2) Fatty Acid Synthase (FASN) (1) Ferroptosis (7) FGFR (2) Flavivirus (1) FLT3 (1) Fluorescent Dye (4) Fungal (8) G-quadruplex (1) GLUT (4) Glutaminase (1) Glutathione Peroxidase (1) Glutathione S-transferase (1) Glycosidase (2) GSK-3 (2) Guanylate Cyclase (1) HCV (1) HDAC (16) Hedgehog (1) Herbicide (1) Histone Acetyltransferase (4) Histone Demethylase (5) Histone Methyltransferase (9) HIV (7) HOXA (1) HPV (2) HSP (8) HuR (2) IAP (1) ICMT (3) IFNAR (1) IKK (1) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Insecticide (1) Insulin Receptor (2) Interleukin Related (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (12) JAK (1) JNK (2) Keap1-Nrf2 (3) Kinesin (1) Lactate Dehydrogenase (1) Large Tumor Suppressor (LATS) (2) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) LIM Kinase (LIMK) (1) Lipoxygenase (2) mAChR (1) MAP3K (1) MASTL (1) MDM-2/p53 (12) MEK (1) Melanocortin Receptor (1) Methionine Adenosyltransferase (MAT) (1) MicroRNA (1) Microtubule/Tubulin (43) Mitochondrial Metabolism (5) Mitosis (1) Mixed Lineage Kinase (1) MMP (4) Molecular Glues (2) mTOR (5) nAChR (1) NADPH Oxidase (2) Necroptosis (5) NEKs (2) NF-κB (14) Nucleoside Antimetabolite/Analog (2) Organoid (1) Oxidative Phosphorylation (1) P-glycoprotein (4) p38 MAPK (5) PAI-1 (3) PAK (1) Parasite (5) PARP (11) PD-1/PD-L1 (2) PERK (1) Phosphatase (4) Phosphodiesterase (PDE) (1) Phosphoglycerate Dehydrogenase (PHGDH) (2) Phospholipase (3) PI3K (11) Pim (5) PKA (2) Polo-like Kinase (PLK) (5) Poly(ADP-ribose) Glycohydrolase (PARG) (1) PPAR (2) Progesterone Receptor (1) PROTAC Linkers (1) PROTAC-Linker Conjugates for PAC (1) PROTACs (28) Proteasome (1) Proton Pump (1) Quinone Reductase (3) RAD51 (1) Raf (4) RANKL/RANK (1) Ras (7) Reactive Oxygen Species (ROS) (26) Reference Standards (30) RET (4) Reverse Transcriptase (7) RGS Protein (1) Ribosomal S6 Kinase (RSK) (1) RIO Kinase (3) RIP kinase (2) ROCK (1) ROR (1) ROS Kinase (2) SARS-CoV (3) Ser/Thr Kinase (1) Ser/Thr Protease (2) Serotonin Transporter (1) Sigma Receptor (2) SphK (1) Src (8) STAT (7) Stearoyl-CoA Desaturase (SCD) (1) STING (4) Survivin (1) Syk (1) Telomerase (7) TGF-beta/Smad (1) TGF-β Receptor (1) Thymidylate Synthase (1) TMV (1) TNF Receptor (3) Topoisomerase (10) Transmembrane Glycoprotein (3) Trk Receptor (3) TrxR (1) ULK (2) VEGFR (12) Wee1 (1) Wnt (2) YAP (2) β-catenin (1)
By Research Areas:	Cancer (527) Cardiovascular Disease (15) Endocrinology (4) Infection (37) Inflammation/Immunology (30) Metabolic Disease (10) Neurological Disease (14)
Click Chemistry:	PROTAC Synthesis (2) Tetrazine (1) Alkynes (1)
Oligonucleotides:	Aptamers (1) Phospholipids (1) Antisense Oligonucleotides (2)

555

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10340

Tirbanibulin 5+ Cited Publications KX2-391; KX-01	Src Microtubule/Tubulin	Cancer
Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

HY-100004

Fumarate hydratase-IN-1 15+ Cited Publications	Mitochondrial Metabolism	Cancer
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC₅₀ of 2.2 μM .

HY-N7083

Citral 1 Publications Verification	Environmental Pollutants Aldehyde Dehydrogenase (ALDH) Apoptosis	Inflammation/Immunology Cancer
Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects ^[2][3].

HY-114305

A1874 2 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC₅₀ of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation .

HY-13915

NSC348884 3 Publications Verification	Apoptosis	Cancer
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC₅₀s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer .

HY-10340A

Tirbanibulin dihydrochloride 5+ Cited Publications KX2-391 dihydrochloride; KX-01 dihydrochloride	Src Microtubule/Tubulin	Cancer
Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

HY-B1785

5-Sulfosalicylic acid 2 Publications Verification Sulfosalicylic acid; Sulphosalicylic acid; Salicylsulfonic acid	Drug Derivative	Cancer
5-Sulfosalicylic acid is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid is effective against the breast cancer cell lines, with less toxicity . 5-Sulfosalicylic acid has antioxidant activities .

HY-P0121

ReACp53 2 Publications Verification	MDM-2/p53	Cancer
ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.

HY-147655

CQ211	RIO Kinase	Cancer
CQ211 is a potent and selective RIOK2 inhibitor with a K_d of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines .

HY-18623

VI 16832	Syk Src	Cancer
VI 16832 is a broad spectrum Type I kinase inhibitor which can be used as an enrichment tool for the comparative expression analysis of protein kinases in different cancer cell lines.

HY-18343A

CP-31398 dihydrochloride	MDM-2/p53	Cancer
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53 .

HY-121250

Fasnall	Fatty Acid Synthase (FASN) Apoptosis	Cancer
Fasnall is a selective fatty acid synthase (FASN) inhibitor with an IC₅₀ of 3.71 μM. Fasnall induces apoptosis in HER2 ⁺ breast cancer cell lines. Fasnall shows potent anti-tumor activities .

HY-108612

VU0155069 CAY10593	Phospholipase	Cancer
VU0155069 (CAY10593), is a selective phospholipase D1 (PLD1) inhibitor with an IC₅₀ value of 46 nM in vitro. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays .

HY-N3119

Paeoniflorigenone	Apoptosis	Cancer
Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect .

HY-10340B

Tirbanibulin Mesylate 5+ Cited Publications KX2-391 Mesylate; KX01 Mesylate	Src Microtubule/Tubulin	Cancer
Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI₅₀ of 9-60 nM in cancer cell lines.

HY-119808

Terrein	Melanocortin Receptor Apoptosis Antibiotic	Cancer
Terrein is a melanogenesis inhibitor . Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa .

HY-N2323

4'-Demethylpodophyllotoxin	Others	Cancer
4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines .

HY-100395

F16	Apoptosis	Cancer
F16 is a potent growth inhibitor of the *neu-overexpressing cells* and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines.

HY-110245

DMH2 1 Publications Verification VU364849	Apoptosis	Cancer
DMH2 is a potent BMP receptor antagonist. DMH2 downregulates the expression of Id1 and Id3 proteins, and inhibits the proliferation and induces cell death of lung cancer cell lines .

HY-115840

ICL-CCIC-0019	Apoptosis	Cancer
ICL-CCIC-0019 is an inhibitor of choline kinase α (CHKα). ICL-CCIC-0019 induces G1 block, endoplasmic reticulum stress apoptosis in cancer cell lines .

HY-108992

Deoxynyboquinone	Quinone Reductase Apoptosis Reactive Oxygen Species (ROS)	Cancer
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-133737

GAL-02-221 PROTAC BRD4 Degrader-5	PROTACs Epigenetic Reader Domain	Cancer
GAL-02-221 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GAL-02-221 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines .

HY-160066

SYL3C aptamer sodium	Transmembrane Glycoprotein	Cancer
SYL3C aptamer sodium is a DNA aptamer targeting EpCAM. SYL3C aptamer sodium targets a variety of cancer cell lines. SYL3C aptamer sodium can be used for targeted cancer cell imaging and circulating tumor cell detection .

HY-123901

Garcinone E	Apoptosis	Cancer
Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .

HY-147402A

Taragarestrant meglumine D-0502 meglumine	Estrogen Receptor/ERR	Cancer
Taragarestrant (D-0502) meglumine is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant meglumine shows potent activity in various ER+ breast cancer cell lines and xenograft models .

HY-148255

QN523	Apoptosis Autophagy	Cancer
QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer .

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N3924

Ganoderiol F	Others	Others
Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .

HY-N0944

(-)-Heraclenol	Others	Cancer
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-150308

SR10221	PPAR	Cancer
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines .

HY-129156

HS-1793	Apoptosis	Cancer
HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines . HS-1793 induces cell apoptosis .

HY-175164

SVC112	Apoptosis c-Myc	Cancer
SVC112 is a translation elongation inhibitor that prevents the cyclic dissociation of EF2 from the ribosome, thereby inhibiting the elongation step of translation. SVC112 shows activity in growth inhibition among cancer cell lines of various origins (acute myeloid leukemia (AML), multiple myeloma (Myeloma), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC)). SVC112 preferentially impedes ribosomal processing of mRNAs, and decreaseds CSC-related proteins including Myc and Sox2. SVC112 induces apoptosis in hematologic cancer cell lines, while phosphorylation of c-Myc correlates with sensitivity to SVC112 in colorectal cancer cell lines. SVC112 inactivates HNSCC stem cells in vitro and prevents the regrowth of HNSCC tumor xenografts in mice. SVC112 can be used for the study of HNSCC .

HY-121199

Germanicol	Apoptosis	Cancer
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-110335

OXA-06 hydrochloride	ROCK	Cancer
OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. OXA-06 hydrochloride inhibits cofilin phosphorylation but does not stimulate apoptosis .

HY-N8375

Sieboldin	Others	Metabolic Disease
Sieboldin is a dihydrochalcone, which inhibits the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA), has free radical scavenging activity and cytotoxicity in cancer cell lines, and is also used to capture of methylglyoxal (MGO) from Malus baccata .

HY-147402

Taragarestrant D-0502	Estrogen Receptor/ERR	Cancer
Taragarestrant (D-0502) is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant shows potent activity in various ER+ breast cancer cell lines and xenograft models .

HY-157297

CDK-IN-13	CDK	Cancer
CDK-IN-13 (compound 32E) is a potent and selective inhibitor of CDK12/cyclinK with an IC₅₀ of 3 nM. CDK-IN-13 inhibits the growth of the HER2-positive breast cancer cell lines .

HY-N8718

Izalpinin	Others	Others
Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

HY-P11007

β-catenin inhibitory peptoid	β-catenin Wnt Androgen Receptor	Cancer
β-catenin inhibitory peptoid (compound 13) inhibits the β-catenin:TCF interaction with an IC₅₀ of 5.44 µM. β-catenin inhibitory peptoid inhibits both Wnt (IC₅₀ of 0.105 µM) and androgen receptor (AR)-signaling (IC₅₀ of 1.02 µM) in prostate cancer cell lines. β-catenin inhibitory peptoid markedly diminishes cell proliferation of prostate cancer cell lines .

HY-N10304

Isodispar B	Apoptosis	Cancer
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines .

HY-150753

RS6212 1 Publications Verification	Oxidative Phosphorylation Lactate Dehydrogenase	Cancer
RS6212 is a specific LDH (lactate dehydrogenase) inhibitor with an IC₅₀ value of 12.03 μM . RS6212 inhibits tumor growth and exhibits potent anticancer activity in multiple cancer cell lines .

HY-101071

(S)-Monastrol (+)-Monastrol	Kinesin Mitosis	Cancer
(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles .

HY-125202

KuWal151	CDK DYRK	Cancer
KuWal151 is a CLK1, CLK2 and CLK4 inhibitor with a high selectivity margin towards DYRK kinases. KuWal151 has potent antiproliferative activity in an array of cultured cancer cell lines .

HY-153519

WWL0245	Epigenetic Reader Domain	Cancer
WWL0245 is a potent and seletive BRD4 PROTAC. WWL0245 selectively degrades BRD4 with sub-nanomolar DC₅₀ (<1 nM) than BRD2/3 and PLK1 ( DC₅₀>1 μM). WWL0245 shows excellent selective cytotoxicity in the BETi sensitive cancer cell lines, including AR-positive prostate cancer cell lines. WWL0245 is a promising drug candidate for AR-positive prostate cancer research and a valuable tool compound to study the biological function of BRD4 .

HY-119377

UPGL00004	Glutaminase	Cancer
UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC₅₀=29 nM; K_d=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines .

HY-N9172

Eupaglehnin C	Others	Cancer
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines .

HY-N2906

Limonianin Atalantoflavone	Parasite	Cancer
Limonianin (Atalantoflavone) is a flavone, that can be isolated from Erythrina sigmoidea and the root bark of Citrus limonia. Limonianin presents inhibitory effect against P. gingivalis. Limonianin shows cytotoxic activity against multidrug-resistant (MDR) cancer cell lines .

HY-161850

ULK1-IN-3	ULK Apoptosis PARP Autophagy NF-κB AMPK Akt Reactive Oxygen Species (ROS)	Cancer
ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines .

HY-178038

Tubulin-IN-56	Microtubule/Tubulin Reactive Oxygen Species (ROS)	Cancer
Tubulin-IN-56 is a tubulin inhibitor. Tubulin-IN-56 exerts cytotoxic effects against colon cancer cell lines (LS180, HCT116, SW620, LoVo). Tubulin-IN-56 downregulates βIII-tubulin and upregulates βIVa-tubulin in colon cancer cell lines. Tubulin-IN-56 inhibits cell invasiveness and elevates intracellular ROS levels in colon cancer cell lines. Tubulin-IN-56 can be used for the study of colon cancer .

HY-116107

AG311	Necroptosis	Cancer
AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines .

Cat. No.	Product Name	Type

HY-15096

MKT-077 15+ Cited Publications FJ-776	Fluorescent Dyes
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .

HY-128952G

Tesirine

SG3249

Fluorescent Dyes

Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

HY-D3158

LGP-CL	Fluorescent Dyes
LGP-CL is a chemiluminescent probe. LGP-CL can be used to evaluate elevated protease levels in both in vitro and in vivo systems, and to distinguish hepatocellular carcinoma cells from normal cells and other cancer cell lines. LGP-CL is applicable to liver cancer-related research .

HY-D3198

NIR‐fluorescent ceramide

Fluorescent Dyes

NIR-fluorescent ceramide is a neutral near-infrared (NIF) fluorescent probe (λ_em=650 nm) based on the C-bridged nitrobenzoxadiazole SCOTfluor core, which enables visualization of lipid metabolic processes such as sphingolipid trafficking. The emission signal of NIR-fluorescent ceramide increases significantly in liposomal environments. NIR-fluorescent ceramide acts as an intracellular trafficking tracer, localizing to regions surrounding the endoplasmic reticulum and Golgi apparatus within a short period, and then translocating to recycling lysosomes over a longer period, thus enabling real-time visualization of sphingolipid trafficking and biological lipid functions in living cells. NIR-fluorescent ceramide also generates metabolic uptake profiles and provides multiple metabolic readouts in human cancer cell lines .

Cat. No.	Product Name	Type

HY-Y1883

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant

20+ Cited Publications

Biochemical Assay Reagents

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a nonionic surfactant. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant induces Apoptosis in prostate and colon cancer cell lines and reduces the infectivity of classic enveloped viruses such as WNV .

HY-B0633E

Hyaluronic acid, low endotoxin

Hyaluronan, low endotoxin; Hyaluronate, low endotoxin

Biochemical Assay Reagents

Hyaluronic acid, low endotoxin (Hyaluronan, low endotoxin) is a biopolymer composed of repeating disaccharide units containing low levels of endotoxin. Hyaluronic acid is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid activates PI3K-Akt signaling. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid can lubricate the corneal endothelium. Hyaluronic acid can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases .

HY-128952G

Tesirine

SG3249

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P0121

ReACp53 2 Publications Verification	MDM-2/p53	Cancer
ReACp53 could inhibit p53 amyloid formation and rescue p53 function in cancer cell lines.

HY-P3717

Targefrin	Ephrin Receptor	Cancer
Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC₅₀ value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines .

HY-P5391

LL-37(17-32)	Bacterial	Others
LL-37(17-32) is a biological active peptide. (This peptide is an active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide. It has been reported that the LL17-32 peptide exhibits reversal effect on ABCG2-mediated multidrug resistance in cancer cell lines.)

HY-P10224A

G7-18NATE TFA	EGFR	Cancer
G7-18NATE TFA is a peptide inhibitor of Grb7. G7-18NATE TFA binds to the Grb7-SH2 domain with micromolar affinity (K_d = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines .

HY-P11007

β-catenin inhibitory peptoid	β-catenin Wnt Androgen Receptor	Cancer
β-catenin inhibitory peptoid (compound 13) inhibits the β-catenin:TCF interaction with an IC₅₀ of 5.44 µM. β-catenin inhibitory peptoid inhibits both Wnt (IC₅₀ of 0.105 µM) and androgen receptor (AR)-signaling (IC₅₀ of 1.02 µM) in prostate cancer cell lines. β-catenin inhibitory peptoid markedly diminishes cell proliferation of prostate cancer cell lines .

HY-P10561

CPK peptide	Peptides	Cancer
CPK peptide is a tumor-localizing peptide. CPK peptide specifically binds to the monocarboxylate transporter 1 (MCT1) receptor, which is overexpressed in many human colon cancer cell lines but not in normal cells. CPK peptide can be used in tumor diagnosis research .

HY-P10224

G7-18NATE	EGFR	Cancer
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (K_D = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines .

HY-P2088

TANDEM Des-N-tetramethyltriostin A	Antibiotic	Cancer
TANDEM (Des-N-tetramethyltriostin A) is a synthetic antibiotic drug that has the activity of inhibiting the growth of tumor cells. TANDEM can be used in combination with chemotherapy to enhance the inhibitory effect. TANDEM has shown significant inhibitory effects on a variety of cancer cell lines in in vitro experiments. The structure of TANDEM allows it to effectively target tumor cells during the inhibition process. TANDEM's mechanism of action involves interfering with cell proliferation and survival pathways .

HY-P10596

Lasioglossin-III	Bacterial Fungal	Infection Cancer
Lasioglossin-III is an antimicrobial peptide that can be isolated from the venom of wild bees. Lasioglossin-III has high antibacterial activity against Gram-positive and Gram-negative bacteria, antifungal activity and antitumor activity. Lasioglossin-III has certain cytotoxicity against three cancer cell lines (HeLa S3, CRC SW 480 and CCRF-CEM T) with IC₅₀ values of 4, 18 and 5 μM, respectively .

HY-P10515

AcrAP2	Bacterial Fungal	Infection Cancer
AcrAP2 is an antimicrobial peptide present in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP2 is inhibitory against Gram-positive bacteria and yeast but is essentially inactive against Gram-negative bacteria. A cation-enhanced AcrAP2 analog (AcrAP2a) exhibits significant antiproliferative effects at low concentrations against certain human cancer cell lines. AcrAP2 can be used in antibacterial and anti-tumor research .

HY-136727A

Ac-LEVD-CHO TFA	Caspase Apoptosis	Cancer
Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines .

HY-P10669

NDI-Lyso	Caspase Apoptosis	Cancer
NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC₅₀ ~10 μM) while showing low toxicity to normal cells (IC₅₀ > 60 μM) .

HY-P11658

Anticancer peptoid 1 Peptoid 1	Peptides	Cancer
Anticancer peptoid 1 (Peptoid 1) is a peptoid with antitumor activity. Anticancer peptoid 1 exerts cytotoxicity primarily via plasma membrane damage. Anticancer peptoid 1 exerts cytotoxicity against a broad range of cancer cell lines, including those with multidrug resistance. Anticancer peptoid 1 inhibits tumor growth in a human breast cancer xenotransplantation mouse model without noticeable acute adverse effects. Anticancer peptoid 1 can be used for the research of cancer, such as breast cancer, and prostate cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-108730

Avelumab Maximum Cited Publications 10 Publications Verification Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C	PD-1/PD-L1	Inflammation/Immunology Cancer
Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma .

HY-108730A

Avelumab (anti-PD-L1) Maximum Cited Publications 10 Publications Verification	PD-1/PD-L1	Inflammation/Immunology Cancer
Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P99011

Cibisatamab 2 Publications Verification	CD3	Cancer
Cibisatamab, a T cell bispecific antibody, binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cell surface. Cibisatamab can be used for colorectal cancer research .

HY-P99413

IMAB027 ASP1650	HCV	Cancer
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6 ⁺ ovarian and testicular cancer cell lines .

HY-P99662

Indusatumab vedotin MLN0264; TAK-264	Antibody-Drug Conjugates (ADCs) Guanylate Cyclase Apoptosis	Cancer
Indusatumab vedotin (MLN-0264; AKT-264) is an antibody-drug conjugate (ADC) consisting of the human anti-guanylate cyclase C (GCC) antibody linked to a microtubule-disruptor Monomethyl auristatin (HY-15162). Indusatumab vedotin has anti-proliferative effects on pancreas cancer cell lines. Indusatumab vedotin arrests cell cycle at G2/M phase, and induces apoptosis .

HY-P991462

GBR-1342	CD38	Cancer
GBR-1342 is a human bispecific antibody (bsAb) targeting CD38 & CD3. GBR-1342 inhibits the activity of Daudi, RAJI, RPMI8226, IM-9, and NCI-H929 cancer cell lines. GBR-1342 can be used in myeloma research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0162

Luteolin Maximum Cited Publications 89 Publications Verification Luteoline; Luteolol; Digitoflavone	Classification of Application Fields Flavones Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite
Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-12033

2-Methoxyestradiol 30+ Cited Publications 2-ME2; NSC-659853	Monophenols Classification of Application Fields Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-N2329

Piperlongumine 10+ Cited Publications Piplartine	Piper longum Linn. Infection Cardiovascular Disease Alkaloids Classification of Application Fields Pyridine Alkaloids Piperaceae Plants Disease Research Fields Source Classification	ERK Reactive Oxygen Species (ROS) Autophagy Apoptosis Bacterial Ferroptosis
Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-N0755

Rhoifolin	Rhus succedanea Flavonoids Classification of Application Fields Flavones Plants Disease Research Fields Endocrinology Anacardiaceae Cancer	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-N7083

Citral 1 Publications Verification	Structural Classification Classification of Application Fields Cymbopogon citratus Ketones, Aldehydes, Acids Gramineae Plants Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Environmental Pollutants Aldehyde Dehydrogenase (ALDH) Apoptosis
Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects ^[2][3].

HY-108692

Enterolactone	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Lignans Phenylpropanoids Endogenous metabolite Disease Research Fields Source Classification Cancer	Apoptosis Endogenous Metabolite
Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-N0255

alpha-Hederin 3 Publications Verification α-Hederin	Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Apoptosis
alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway .

HY-101984

N6,N6-Dimethyladenosine 4 Publications Verification	Microorganisms Marine natural products Source Classification	Nucleoside Antimetabolite/Analog Adenosine Receptor Akt SARS-CoV
N6,N6-Dimethyladenosine, a modified ribonucleoside, is an endogenous A3 adenosine receptor ligand. N6,N6-Dimethyladenosine is an AKT inhibitor with antitumor effects. N6, N6-Dimethyladenosine targets SARS-CoV-2 entry protein ADAM17. N6, N6-Dimethyladenosine robustly inhibits AKT signaling in a variety of non-small cell lung cancer cell lines .

HY-N2081

Skimmianine 3 Publications Verification	Alkaloids Classification of Application Fields Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N0162R

Luteolin (Standard) Maximum Cited Publications 89 Publications Verification Luteoline(Standard); Luteolol(Standard); Digitoflavone (Standard)	Human Gut Microbiota Metabolites Flavonoids other families Classification of Application Fields Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite
Luteolin (Standard) is the analytical standard of Luteolin. This product is intended for research and analytical applications. Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1 and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-N3119

Paeoniflorigenone	Classification of Application Fields Ketones, Aldehydes, Acids Plants Paeoniaceae Disease Research Fields Cancer Source Classification Paeonia suffruticosa Andr.	Apoptosis
Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect .

HY-N2323

4'-Demethylpodophyllotoxin	Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields Source Classification Cancer	Others
4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines .

HY-N4286

4-Methyldaphnetin	other families Classification of Application Fields Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer Source Classification	Apoptosis
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .

HY-N1243

Tubulysin B	Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-121382

Gypsogenin	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Disease Research Fields Caryophyllaceae Source Classification Gypsophila perfoliata Linn.	Cholinesterase (ChE) Apoptosis Necroptosis
Gypsogenin is a selective mixed-type BChE inhibitor (K_i=19.99 μM) that also exhibits significant cytotoxicity against various human cancer cell lines. Gypsogenin inhibits tumor growth by inducing cell cycle arrest and triggering apoptosis. Gypsogenin displays antibacterial activity against bacteria such as Bacillus subtilis and Bacillus thuringiensis, and often serves as a key parent nucleus for the synthesis of anticancer compounds. Gypsogenin is widely used in research on Alzheimer's disease and various cancers including colon cancer, melanoma, and leukemia .

HY-123901

Garcinone E	Flavonoids Guttiferae Garcinia mangostana Linn. Plants Other Flavonoids Source Classification	Apoptosis
Garcinone E is a natural xanthone found in the rind of the mangosteen fruit. Garcinone E induces apoptosis and inhibits cancer cell migration. Garcinone E has anticancer effects on different human cancer cell lines, including colorectal, breast, and hepatocellular carcinomas .

HY-157647

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC PC(18:0/22:4)	Structural Classification Endogenous metabolite Lipid Source Classification	CDK Apoptosis
1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) is an inhibitor of cyclin-dependent kinases (CDKs). 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC induces apoptosis and inhibits the growth of various cancer cell lines .

HY-N3057

Pinostrobin chalcone	Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Disease Research Fields Cajanus cajan (L.) Millsp. Source Classification Cancer	Others
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N7083R

Citral (Standard)	Structural Classification Microorganisms Cymbopogon citratus Ketones, Aldehydes, Acids Gramineae Plants Source Classification	Reference Standards Apoptosis Aldehyde Dehydrogenase (ALDH)
Citral (Standard) is the analytical standard of Citral. This product is intended for research and analytical applications. Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects .

HY-N3924

Ganoderiol F	Triterpenes Microorganisms Terpenoids Source Classification	Others
Ganoderiol F, a tetracyclic triterpene, is isolated from Ganoderma amboinense and found to induce senescence of cancer cell lines .

HY-N0944

(-)-Heraclenol	Natural Products other families Classification of Application Fields Plants Disease Research Fields Cancer Source Classification	Others
(-)-Heraclenol is a derivative of furocoumarin isolated from Ducrosia anethifolia. (-)-Heraclenol shows antiproliferative and cytotoxic activities on cancer cell lines .

HY-121199

Germanicol	Triterpenes Euphorbia boetica Terpenoids Euphorbiaceae Plants Source Classification	Apoptosis
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-N8375

Sieboldin	Balanophora involucrata Hook. f. Plants Balanophoraceae Saccharides Monosaccharides Source Classification	Others
Sieboldin is a dihydrochalcone, which inhibits the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA), has free radical scavenging activity and cytotoxicity in cancer cell lines, and is also used to capture of methylglyoxal (MGO) from Malus baccata .

HY-N10113

Verrucarin J 1 Publications Verification Muconomycin B	Infection Natural Products Microorganisms Classification of Application Fields Marine algae Marine natural products Disease Research Fields Source Classification	Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species (ROS)
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL .

HY-101984R

N6,N6-Dimethyladenosine (Standard)	Microorganisms Source Classification	Reference Standards Nucleoside Antimetabolite/Analog Adenosine Receptor Akt SARS-CoV
N6,N6-Dimethyladenosine (Standard) is the analytical standard of N6,N6-Dimethyladenosine (HY-101984). This product is intended for research and analytical applications. N6,N6-Dimethyladenosine, a modified ribonucleoside, is an endogenous A3 adenosine receptor ligand. N6,N6-Dimethyladenosine is an AKT inhibitor with antitumor effects. N6, N6-Dimethyladenosine targets SARS-CoV-2 entry protein ADAM17. N6, N6-Dimethyladenosine robustly inhibits AKT signaling in a variety of non-small cell lung cancer cell lines.

HY-108692R

Enterolactone (Standard)	Human Gut Microbiota Metabolites Microorganisms Lignans Phenylpropanoids Endogenous metabolite Source Classification	Reference Standards Apoptosis Endogenous Metabolite
Enterolactone (Standard) is the analytical standard of Enterolactone. This product is intended for research and analytical applications. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-119833

Rubone	Chalcones Flavonoids Leguminosae Plants Source Classification Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets .

HY-N8718

Izalpinin	Muntingia calabura L. Plants Muntingiaceae Source Classification	Others
Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura .

HY-N10304

Isodispar B	Lycoris radiata (L’Her.) Herb. Coumarins Phenylpropanoids Plants Amaryllidaceae Source Classification	Apoptosis
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines .

HY-N9172

Eupaglehnin C	Terpenoids Sesquiterpenes Erythrina poeppigiana Plants Compositae Source Classification	Others
Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines .

HY-N2906

Limonianin Atalantoflavone	Flavonoids Flavones Rutaceae Atalantia buxifolia (Poir.) Oliv. Plants Source Classification	Parasite
Limonianin (Atalantoflavone) is a flavone, that can be isolated from Erythrina sigmoidea and the root bark of Citrus limonia. Limonianin presents inhibitory effect against P. gingivalis. Limonianin shows cytotoxic activity against multidrug-resistant (MDR) cancer cell lines .

HY-N1066

Xanthohumol D 1 Publications Verification	Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Phenols Polyphenols Plants Moraceae Disease Research Fields Source Classification Cancer	Others
Xanthohumol D, isolated from hops, is an inhibitor of quinone reductase-2 (QR-2) with the IC₅₀ value of 110 μM, and binds to the active site of QR-2. Xanthohumol D shows antiproliferative activity on human cancer cell lines in vitro .

HY-W663230

Eugenitin	Natural Products Microorganisms Source Classification	Parasite
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD₅₀=39.9 μM. Eugenitin has low cytotoxicity (IC₅₀ >131 μM) against several human cancer cell lines .

HY-W741940

Evomonoside	Apocynaceae Structural Classification Thevetia ahouai (L.) A. DC. Cardiacglycosides Thevetia peruviana (Pers.) K. Schum. Plants Steroids Source Classification	Others
Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer .

HY-N10777

1-Ketoaethiopinone	Ardisia crenata Sims Terpenoids Diterpenoids Plants Myrsinaceae Source Classification	Others
1-Ketoaethiopinone is an abietane-diterpenoid. 1-Ketoaethiopinone has an α, β-unsaturated carbonyl function. 1-Ketoaethiopinone shows cytotoxic activity against human cancer cell lines MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) .

HY-N2329R

Piperlongumine (Standard) Piplartine (Standard)	Piper longum Linn. Alkaloids Structural Classification Pyridine Alkaloids Piperaceae Plants Source Classification	Reference Standards ERK Reactive Oxygen Species (ROS) Autophagy Apoptosis Bacterial Ferroptosis
Piperlongumine is a alkaloid , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities . Piperlongumine induces ROS, and induces apoptosis in cancer cell lines . Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome .

HY-N6844

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol	Natural Products other families Classification of Application Fields Plants Disease Research Fields Cancer Source Classification	Others
8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol also shows marked antipro-liferative activity against human cancer cell lines in vitro .

HY-125916

Pseurotin A	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Pseurotin A is a secondary metabolite of Aspergillus and other fungi. Pseurotin A is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC₅₀ = 3.6 μM). Pseurotin A inhibits the PCSK9-LDLr interaction. Pseurotin A shows dose-dependent reduction of PCSK9, along with increased LDLR levels in hormone-dependent breast cancer cell lines. Pseurotin A exhibits antitumor activity .

HY-N3248

Momordicoside G Momordicacoside G	Triterpenes Terpenoids Cucurbitaceae Plants Source Classification Momordica charantia Linn.	Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury .

HY-N0755R

Rhoifolin (Standard)	Structural Classification Rhus succedanea Flavonoids Flavones Plants Anacardiaceae	Reference Standards Insulin Receptor GLUT NF-κB p38 MAPK Autophagy
Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-N2081R

Skimmianine (Standard)	Alkaloids Structural Classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Source Classification	Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-129584

Lepidiline B	Alkaloids Other Alkaloids Plants Brassicaceae Source Classification Lepidium meyenii Walp.	Others
Lepidiline B is a flavonolignan isolated from the roots of Brassicaceae Lepidium meyenii. Lepidiline B exhibits anti-inflammation activities in human cancer cell lines .

HY-122948

Isogambogenic acid	Flavonoids Guttiferae Plants Garcinia hanburyi Hook. f. Other Flavonoids	Others
Isogambogenic acid is a natural product that can be isolated from Resina Garciniae. Isogambogenic acid has cytotoxicity to cancer cell lines with IC₅₀ values of 0.4327-5.942 μmol/L .

HY-114646

TMC-205	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Cancer Source Classification	Endogenous Metabolite
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .

HY-N12782

Strospeside Gitoxigenin 3-O-monodigitaloside	Cuscuta reflexa Roxb. Plants Convolvulaceae Saccharides Monosaccharides Source Classification	Others
Strospeside (Gitoxigenin 3-O-monodigitaloside) is a cardenolide and can be isolated from Cuscuta shoot. Strospeside has potent cytotoxicity against renal and prostate cancer cell lines .

HY-N6997

Ceratamine A	Alkaloids Animals Classification of Application Fields Other Alkaloids Marine natural products Sponge Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines .

HY-N5208

YM-216391	Natural Products Microorganisms Source Classification	Others
YM-216391 is an antitumor cyclic peptide that can be isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. YM-216391 exhibits potent cytotoxic activity against a variety of human cancer cell lines and can be used in anticancer research .

HY-N3451

Isothymusin	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Piliostigma thonningii (Schumach.) Milne-Redh. Plants Disease Research Fields Source Classification Cancer	Lipoxygenase
Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5 .

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Source Classification	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .

Cat. No.	Product Name	Chemical Structure

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-19542S1

C6 Ceramide-d11
C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-138642S

Vepdegestrant-d5

Vepdegestrant-d₅ (ARV-471-d₅) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC₅₀ of about 2 nM .

HY-19822S

Elacestrant-d4
Elacestrant-d₄ (RAD1901-d₄) is a deuterated labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-108692S

Enterolactone-d6
Enterolactone-d₆ is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-19822S2

Elacestrant-d10
Elacestrant-d₁₀ is the deuterium labeled of Elacestrant (HY-19822). Elacestrant is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also inhibits growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

HY-170905S

MAT2A-IN-22
MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active MAT2A inhibitor with an IC₅₀ of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects .

HY-W778286

Enterolactone-13C3
Enterolactone- ¹³C₃ is the ¹³C-labeled Enterolactone (HY-108692). Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity . Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis .

HY-19822S3

Elacestrant-d6
Elacestrant-d₆ (RAD1901-d₆) is a deuterated labeled Elacestrant (HY-19822). Elacestrant is a selective estrogen receptor (estrogen receptor, ER) degrader (SERD) with oral activity, with IC₅₀ values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant can also effectively inhibit the growth of ER ⁺ breast cancer cell lines both in vitro and in vivo.

HY-19822S4

Elacestrant-d5
Elacestrant-d₅ (RAd₁₉01-d₅) is the deuterium labeled Elacestrant (HY-19822). Elacestrant (RAD1901) is an orally available and selective estrogen receptor degrader (SERD) with IC₅₀s of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant also can inhibit growth of ER ⁺ breast cancer cell lines in vitro and in vivo .

HY-180885S

KRAS G12D-IN-35
KRAS G12D-IN-35 (example 7) is a potent and orally active KRAS G12D inhibitor. KRAS G12D-IN-35 suppresses p-ERK in AGS cells and potently inhibits the proliferation of various KRAS G12D-mutant cancer cell lines. KRAS G12D-IN-35 inhibits tumor growth in HPAC and GP2D mouse models. KRAS G12D-IN-35 can be used for cancer research, such as pancreatic and colorectal cancer .

Cat. No.	Product Name		Classification

HY-139659

ARD-61		PROTAC Synthesis
ARD-61 is a highly potent, effective and specific PROTAC androgen receptor (AR) degrader. ARD-61 potently and effectively induces AR and progesterone receptors (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and effectively induces tumor growth inhibition in the MDA-MB-453 xenograft model in mice . ARD-61 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-133020

ARD-266		PROTAC Synthesis
ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC₅₀ values of 0.2-1 nM . ARD-266 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-169098

HSP90/LSD1-IN-1		Alkynes
HSP90/LSD1-IN-1 (compound 6) is a HSP90/LSD1 dual inhibitor. HSP90/LSD1-IN-1 inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI₅₀ values of 0.24 and 0.30 μM, respectively .

HY-179232

ERα antagonist 2		Tetrazine
ERα antagonist 2 (Compound 5b) is an ER-α antagonist with an IC₅₀ value of 1729 nM. ERα antagonist 2 exhibits significant inhibitory activity against breast cancer cell lines, and is still effective against ER-negative cells (MDA-MB-231), suggesting the existence of ER-independent pathways. ERα antagonist 2 can be used for the study of breast cancer .

Cat. No.	Product Name		Classification

HY-160066

SYL3C aptamer sodium		Aptamers
SYL3C aptamer sodium is a DNA aptamer targeting EpCAM. SYL3C aptamer sodium targets a variety of cancer cell lines. SYL3C aptamer sodium can be used for targeted cancer cell imaging and circulating tumor cell detection .

HY-157647

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC PC(18:0/22:4)		Phospholipids
1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC (PC(18:0/22:4)) is an inhibitor of cyclin-dependent kinases (CDKs). 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PC induces apoptosis and inhibits the growth of various cancer cell lines .

HY-148827A

GEM-231 sodium HYBO-165 sodium		Antisense Oligonucleotides
GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

HY-148827

GEM-231 HYBO-165		Antisense Oligonucleotides
GEM231 is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128952G

Tesirine SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

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