CQ627
Based on 1 Customer Validation
CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model.
For research use only. We do not sell to patients.
- Purity: 98.93%
- CAS No.: 3093767-34-8
- Formula: C36H27F4N7O4
- Molecular Weight:697.64
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
RIOK2 |
Chemical Information
-
CAS No. 3093767-34-8
-
Appearance Solid
-
Molecular Weight 697.64
-
Formula C36H27F4N7O4
-
Color White to light yellow
-
SMILES
FC1=CC=C(C(/C=C/C(N2CCN(C3=C(C(F)(F)F)C=C(N4N=NC5=C4C6=CC(C7=CC=C(OC)N=C7)=CC=C6NC5=O)C=C3)CC2)=O)=O)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (28.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4334 mL | 7.1670 mL | 14.3340 mL | 35.8351 mL |
| 5 mM | 0.2867 mL | 1.4334 mL | 2.8668 mL | 7.1670 mL | |
| 10 mM | 0.1433 mL | 0.7167 mL | 1.4334 mL | 3.5835 mL | |
| 15 mM | 0.0956 mL | 0.4778 mL | 0.9556 mL | 2.3890 mL | |
| 20 mM | 0.0717 mL | 0.3584 mL | 0.7167 mL | 1.7918 mL | |
| 25 mM | 0.0573 mL | 0.2867 mL | 0.5734 mL | 1.4334 mL |
Powered by Bioz