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Cat. No.: HY-156919

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p53 Activator 8

p53 Activator 8 (compound 5) is a p53 activator. p53 Activator 8 has potent anti-proliferative activity against MCF7 breast cancer cell lines with an IC⁵⁰ value of 0.5 μM.

For research use only. We do not sell to patients.

CAS No.: 1426937-93-0
Formula: C₁₅H₁₇NO₂S
Molecular Weight:275.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

p53 Activator 8 Chemical Structure

CAS No.: 1426937-93-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

p53 Activator 8 (compound 5) is a p53 activator. p53 Activator 8 has potent anti-proliferative activity against MCF7 breast cancer cell lines with an IC⁵⁰ value of 0.5 μM^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	13.2 μM Compound: 1; MANIO	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
HCC1806	IC₅₀	>100 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 24 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 24 hrs by MTT assay	[PMID: 24747064]
HCC1806	IC₅₀	28.7 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 96 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 96 hrs by MTT assay	[PMID: 24747064]
HCC1806	IC₅₀	63.1 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 48 hrs by MTT assay	[PMID: 24747064]
HCC1806	IC₅₀	78.5 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 72 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	>100 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 24 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	11.8 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 96 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 96 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	14.8 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	56.8 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 24747064]
HCT-116	IC₅₀	0.97 μM Compound: 1; MANIO	Antiproliferative activity against wildtype p53 expressing human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against wildtype p53 expressing human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
HCT-116	IC₅₀	0.97 μM Compound: 21; MANIO	Antiproliferative activity against human HCT-116 cells expressing wild type p53 measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells expressing wild type p53 measured after 48 hrs by MTT assay	[PMID: 38142509]
HCT-116	IC₅₀	48.25 μM Compound: 1; MANIO	Antiproliferative activity against human HCT-116 cells expressing p53-/- assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human HCT-116 cells expressing p53-/- assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
MCF7	IC₅₀	0.3 μM Compound: 36	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 23313634]
MCF7	IC₅₀	0.54 μM Compound: 36	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23313634]
MCF7	IC₅₀	0.54 μM Compound: 36	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23313634]
MCF7	IC₅₀	1.75 μM Compound: 36	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 23313634]
MDA-MB-231	IC₅₀	>50 μM Compound: 1; MANIO	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
PANC-1	IC₅₀	42.15 μM Compound: 1; MANIO	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]

Chemical Information

CAS No. 1426937-93-0
Molecular Weight 275.37
Formula C₁₅H₁₇NO₂S
SMILES

CC1=C(CO)C(CO)=C2N1[C@H](C3=CC=CC=C3)SC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. ATAÍDE SARAIVA, et al. WO2019243906. 2019.

[2]. Maria I L Soares, et al. Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties. Eur J Med Chem. 2013. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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