p53 Activator 8

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p53 Activator 8 (compound 5) is a p53 activator. p53 Activator 8 has potent anti-proliferative activity against MCF7 breast cancer cell lines with an IC⁵⁰ value of 0.5 μM.

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p53 Activator 8 Chemical Structure

CAS No. : 1426937-93-0

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Description

p53 Activator 8 (compound 5) is a p53 activator. p53 Activator 8 has potent anti-proliferative activity against MCF7 breast cancer cell lines with an IC⁵⁰ value of 0.5 μM^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	13.2 μM Compound: 1; MANIO	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
HCC1806	IC₅₀	28.7 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 96 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 96 hrs by MTT assay	[PMID: 24747064]
HCC1806	IC₅₀	63.1 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 48 hrs by MTT assay	[PMID: 24747064]
HCC1806	IC₅₀	78.5 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 72 hrs by MTT assay	[PMID: 24747064]
HCC1806	IC₅₀	> 100 μM Compound: 6	Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 24 hrs by MTT assay Antiproliferative activity against ER, PR, HER2-deficient human HCC1806 cells as growth inhibition after 24 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	11.8 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 96 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 96 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	14.8 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	56.8 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 24747064]
HCC1954	IC₅₀	> 100 μM Compound: 6	Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 24 hrs by MTT assay Antiproliferative activity against human HCC1954 cells expressing HER2 assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 24747064]
HCT-116	IC₅₀	0.97 μM Compound: 1; MANIO	Antiproliferative activity against wildtype p53 expressing human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against wildtype p53 expressing human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
HCT-116	IC₅₀	0.97 μM Compound: 21; MANIO	Antiproliferative activity against human HCT-116 cells expressing wild type p53 measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells expressing wild type p53 measured after 48 hrs by MTT assay	[PMID: 38142509]
HCT-116	IC₅₀	48.25 μM Compound: 1; MANIO	Antiproliferative activity against human HCT-116 cells expressing p53-/- assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human HCT-116 cells expressing p53-/- assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
MCF7	IC₅₀	0.3 μM Compound: 36	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 23313634]
MCF7	IC₅₀	0.54 μM Compound: 36	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23313634]
MCF7	IC₅₀	0.54 μM Compound: 36	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23313634]
MCF7	IC₅₀	1.75 μM Compound: 36	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 23313634]
MDA-MB-231	IC₅₀	> 50 μM Compound: 1; MANIO	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]
PANC-1	IC₅₀	42.15 μM Compound: 1; MANIO	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB assay	[PMID: 38784460]

Molecular Weight

275.37

Formula

C₁₅H₁₇NO₂S

CAS No.

1426937-93-0

SMILES

CC1=C(CO)C(CO)=C2N1[C@H](C3=CC=CC=C3)SC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. ATAÍDE SARAIVA, et al. WO2019243906. 2019.

[2]. Maria I L Soares, et al. Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties. Eur J Med Chem. 2013. [Content Brief]

p53 Activator 8 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Activator 81426937-93-0MDM-2/p53p53 ActivatorAntitumorInhibitorinhibitorinhibit

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p53 Activator 8

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