2. Apoptosis
  3. Apoptosis
  4. Paeoniflorigenone

Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect.

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Paeoniflorigenone Chemical Structure

Paeoniflorigenone Chemical Structure

CAS No. : 80454-42-8

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Paeoniflorigenone Related Antibodies

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Description

Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect[1].

In Vitro

Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines[1].
Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Paeoniflorigenone Related Antibodies

Cell Proliferation Assay[1]

Cell Line: TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells
Concentration: 0-30 μM
Incubation Time: 0-72 hours
Result: Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines.

Apoptosis Analysis[1]

Cell Line: TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells)
Concentration: 0, 1, 3, 10, 30 μM
Incubation Time: 24 and 72 hours
Result: Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.
Molecular Weight

318.32

Formula

C17H18O6
CAS No.
Appearance

Oil

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)OC[C@H]2[C@@H]3O[C@@]4(C[C@H]2C(C[C@@]4(O3)C)=O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Paeoniflorigenone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paeoniflorigenone80454-42-8ApoptosiscancerHL60JurkatHeLacellsantiproliferativeDNAInhibitorinhibitorinhibit

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