1. Apoptosis
  2. Apoptosis
  3. Paeoniflorigenone

Paeoniflorigenone 

Cat. No.: HY-N3119 Purity: ≥98.0%
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Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect.

For research use only. We do not sell to patients.

Paeoniflorigenone Chemical Structure

Paeoniflorigenone Chemical Structure

CAS No. : 80454-42-8

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect[1].

In Vitro

Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines[1].
Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells
Concentration: 0-30 μM
Incubation Time: 0-72 hours
Result: Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines.

Apoptosis Analysis[1]

Cell Line: TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells)
Concentration: 0, 1, 3, 10, 30 μM
Incubation Time: 24 and 72 hours
Result: Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.
Molecular Weight

318.32

Formula

C₁₇H₁₈O₆

CAS No.

80454-42-8

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

PaeoniflorigenoneApoptosiscancerHL60JurkatHeLacellsantiproliferativeDNAInhibitorinhibitorinhibit

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