Paeoniflorigenone
Based on 1 Customer Validation
Paeoniflorigenone, isolated as an active ingredient from the root of moutan cortex, induces apoptosis selectively in the cancer cell lines and exhibits antiproliferative effect.
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- Reinheit: 98.50%
- CAS. Nr.: 80454-42-8
- Formel: C17H18O6
- Molecular Weight:318.32
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
6.87 μM
Compound: 25
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction
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[PMID: 23067550] |
Paeoniflorigenone (0-30 μM; 0-72 hours) significantly decreases the cell proliferation of tumor cell lines and inhibits the proliferation of normal cell lines[1].
Paeoniflorigenone (0-30 μM; 24-72 hours) significantly induces apoptotic DNA fragmentation selectively in tumor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TIG-1, 3T3-L1, HL60, Jurkat and HeLa cells
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Concentration:0-30 μM
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Incubation Time:0-72 hours
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Result:Significantly decreased the cell proliferation of tumor cell lines and inhibited the proliferation of normal cell lines.
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Cell Line:TIG-1 and 3T3-L1 (normal cells), HL60, Jurkat, and HeLa cells (tumor cells)
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Concentration:0, 1, 3, 10, 30 μM
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Incubation Time:24 and 72 hours
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Result:Induced DNA fragmentation in three tumor cell lines, but not in two normal cell lines.
Chemical Information
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CAS. Nr. 80454-42-8
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Appearance Oil
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Molecular Weight 318.32
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Formel C17H18O6
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C1)OC[C@H]2[C@@H]3O[C@@]4(C[C@H]2C(C[C@@]4(O3)C)=O)O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Paeoniflorigenone Related Classifications
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