1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Tubulin polymerization-IN-2

Tubulin polymerization-IN-2 

Cat. No.: HY-143247
Handling Instructions

Tubulin polymerization-IN-2 is a potent anticancer agent targeting to β-tubulin with an IC50 value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-2 Chemical Structure

Tubulin polymerization-IN-2 Chemical Structure

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Description

Tubulin polymerization-IN-2 is a potent anticancer agent targeting to β-tubulin with an IC50 value of 0.92 μM. Tubulin polymerization-IN-2 shows promising activity against various leukemia, non-small lung, renal, prostate, and breast cancer cell lines[1].

IC50 & Target

IC50: 0.92 μM (tubulin)[1]

In Vitro

Tubulin polymerization-IN-2 (compound 2b) shows anti-cancer activity against epidermal carcinoma and breast carcinoma with IC50s of 2.3 μM (KB) and 2.2 μM (BT-549), respectively[1].
Tubulin polymerization-IN-2 (0.342 μM; 24 h) inhibits DNA synthesis or repair, arrests cell cycle at S phase in MCF-7 cells[1].
Tubulin polymerization-IN-2 (0.342 μM; 24 h) induces cell apoptosis by decreasing Bax, APAF-1, and caspase-3 expression and increasing BCL-2 mRNA abundance[1].
Tubulin polymerization-IN-2 (0.01, 0.1, 1, 10 μM; 1 h) has strong interactions on β-tubulin polymerization, with Ki value of 0.09 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

314.29

Formula

C17H12F2N2O2

SMILES

COC1=CC2=C(C(C(C#N)=C(O2)N)C3=CC(F)=C(C=C3)F)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Tubulin polymerization-IN-2
Cat. No.:
HY-143247
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