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Cat. No.: HY-119548

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Bifidenone

Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines.

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CAS No.: 2078008-57-6
화학식: C₂₁H₂₆O₅
분자량:358.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Bifidenone Chemical Structure

CAS No.: 2078008-57-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Bifidenone is a tubulin polymerization inhibitor that exhibits antiproliferative activity against a range of human cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	0.075 μM Compound: 2	Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human A375 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
ACHN	IC₅₀	0.36 μM Compound: 2	Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human ACHN cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
HCC 2998	IC₅₀	1.41 μM Compound: 2	Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay Antiproliferative activity against human HCC2998 cells after 48 hrs by SRB assay	[PMID: 28335606]
M14	IC₅₀	0.064 μM Compound: 2	Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human M14 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
M14	IC₅₀	0.11 μM Compound: 4a	Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay Antiproliferative activity against human M14 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay	[PMID: 29995409]
Malme-3M	IC₅₀	<0.1 μM Compound: 2	Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay Antiproliferative activity against human MALME-3M cells after 48 hrs by SRB assay	[PMID: 28335606]
MDA-MB-435	IC₅₀	<0.1 μM Compound: 2	Antiproliferative activity against human MDA-MB-435 cells after SRB assay Antiproliferative activity against human MDA-MB-435 cells after SRB assay	[PMID: 28335606]
NCI/ADR-RES	IC₅₀	0.17 μM Compound: 2	Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay Antiproliferative activity against human NCI-ADR-RES cells after 48 hrs by SRB assay	[PMID: 28335606]
NCI-H460	IC₅₀	0.26 μM Compound: 2	Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
NCI-H460	IC₅₀	0.26 μM Compound: 4a	Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by CellTiter 96 aqueous nonradioactive cell proliferation assay	[PMID: 29995409]
PC-3	IC₅₀	0.49 μM Compound: 2	Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human PC3 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
RAW264.7	IC₅₀	>5 μM Compound: 2	Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against mouse RAW264.7 cells after 18 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SF-295	IC₅₀	0.25 μM Compound: 2	Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human SF295 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SK-MEL-2	IC₅₀	0.095 μM Compound: 2	Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human SK-MEL-2 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]
SR	IC₅₀	<0.1 μM Compound: 2	Antiproliferative activity against human SR cells after 48 hrs by SRB assay Antiproliferative activity against human SR cells after 48 hrs by SRB assay	[PMID: 28335606]
UACC-62	IC₅₀	0.044 μM Compound: 2	Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay Antiproliferative activity against human UACC62 cells after 72 hrs by CellTiter96 AQueous nonradioactive cell proliferation assay	[PMID: 28335606]

Chemical Information

CAS No. 2078008-57-6
분자량 358.43
화학식 C₂₁H₂₆O₅
SMILES

O=C1C=C2OCO[C@]2(C[C@@H]1CC=C)[C@H](CC3=CC=C(C(OC)=C3)OC)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang Z, Williams RB, O'Neil-Johnson M, Eldridge GR, Mangette JE, Starks CM. A Total Synthesis of Bifidenone. J Org Chem. 2017 Apr 21;82(8):4235-4241. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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