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Cat. No.: HY-164549

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XMD15-44

XMD15-44 is a RET kinase inhibitor.XMD15-44 has a growth-inhibitory effect on RET/C634R and RET/M918T transformed RAT1 cells, with IC₅₀ values of 11.5 nM and 8.3 nM, respectively. XMD15-44 can inhibit RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles, reducing cell proliferation.

For research use only. We do not sell to patients.

CAS No.: 1240489-67-1
Formula: C₂₉H₂₉F₃N₄O
Molecular Weight:506.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

XMD15-44 Chemical Structure

CAS No.: 1240489-67-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	EC₅₀	<0.001 μM Compound: 3	Antiproliferative activity against mouse BAF3 cells expressing wild type Bcr-Abl Antiproliferative activity against mouse BAF3 cells expressing wild type Bcr-Abl	[PMID: 20541934]
BaF3	EC₅₀	0.092 μM Compound: 3	Antiproliferative activity against mouse BAF3 cells expressing Bcr-Abl T315I mutant Antiproliferative activity against mouse BAF3 cells expressing Bcr-Abl T315I mutant	[PMID: 20541934]
BaF3	EC₅₀	1.59 μM Compound: 3	Antiproliferative activity against mouse BAF3 cells Antiproliferative activity against mouse BAF3 cells	[PMID: 20541934]

Chemical Information

CAS No. 1240489-67-1
Molecular Weight 506.56
Formula C₂₉H₂₉F₃N₄O
SMILES

CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moccia M, et al. Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. PLoS One. 2015 Jun 5;10(6):e0128364. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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