1240489-67-1

XMD15-44 Chemical Structure
1240489-67-1

Chemical Structure

XMD15-44

  • CAS No.: 1240489-67-1
  • Formula:C29H29F3N4O
  • Molecular Weight:506.56

InChIKey: NIEOGXWKNYZXLD-UHFFFAOYSA-N

SMILES: CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=CC=C4

Biological Activity: XMD15-44 is a RET kinase inhibitor.XMD15-44 has a growth-inhibitory effect on RET/C634R and RET/M918T transformed RAT1 cells, with IC50 values of 11.5 nM and 8.3 nM, respectively. XMD15-44 can inhibit RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles, reducing cell proliferation[1].

Cat. No. Product Name Purity Description Pricing
HY-164549 		XMD15-44 XMD15-44 is a RET kinase inhibitor.XMD15-44 has a growth-inhibitory effect on RET/C634R and RET/M918T transformed RAT1 cells, with IC50 values of 11.5 nM and 8.3 nM, respectively. XMD15-44 can inhibit RET kinase and signaling in human thyroid cancer cell lines carrying oncogenic RET alleles, reducing cell proliferation.
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