cBu-Cit-GAL-02-221
For research use only. We do not sell to patients.
- CAS No.: 2417369-73-2
- Formula: C79H99ClN16O16S2
- Molecular Weight:1628.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
The STEAP1−3a-D2 PAC with a DAR of 1.7, constructed using cBu-Cit-GAL-02-221 (cBu-Cit-PROTAC BRD4 Degrader-5), degrades BRD4 in STEAP1-overexpressing PC3-S1 cells after 72 h of treatment. The absolute DC50 of the conjugate is 48 μg/mL, the DC50 calculated based on payload equivalent is 556 nM, and the maximum reduction level of BRD4 reaches 55%[1].
The DAR 5.7 STEAP1−3a-D6 PAC constructed from cBu-Cit-GAL-02-221 degrades BRD4 in PC3-S1 cells after 72 h of treatment. Its absolute DC50 value is 0.21 μg/mL, the DC50 calculated on a payload equivalent basis is 7.9 nM, and the maximum reduction level of BRD4 reaches 70%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417369-73-2
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Molecular Weight 1628.31
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Formula C79H99ClN16O16S2
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SMILES
CC1=C(C)SC(N2C3=NN=C2C)=C1C(C4=CC=C(C=C4)Cl)=N[C@H]3CC(NCCOCCOCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(NCC(C=C6)=CC=C6C7=C(C)N=CS7)=O)OCNC(OCC8=CC=C(NC([C@@H](NC(C9(C(NCCCCCN%10C(C=CC%10=O)=O)=O)CCC9)=O)CCCNC(N)=O)=O)C=C8)=O)=O)C(C)(C)C)=O)=O
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Synonyms
cBu-Cit-PROTAC BRD4 Degrader-5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cBu-Cit-GAL-02-221 Related Classifications
HY-160694 Related Classifications
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