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Cat. No.: HY-N15614

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Cassamine

Cassamine is a diterpenoid compound that can be isolated from the bark of Erythrophleum fordii. Cassamine exhibits certain cytotoxicity against non-small cell lung cancer cell lines, with IC₅₀ values of 3.4, 2.1, and 1.9 μM against A549, NCI-H1975, and NCI-H1299, respectively. Cassamine has antitumor activity and can be used in the research of lung cancer and other tumors.

For research use only. We do not sell to patients.

CAS No.: 471-71-6
Formula: C₂₅H₃₉NO₅
Molecular Weight:433.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Cassamine Chemical Structure

CAS No.: 471-71-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.4 μM Compound: 10	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 28506750]
NCI-H1299	IC₅₀	1.9 μM Compound: 10	Cytotoxicity against human NCI-H1299 cells by MTT assay Cytotoxicity against human NCI-H1299 cells by MTT assay	[PMID: 28506750]
NCI-H1975	IC₅₀	2.1 μM Compound: 10	Cytotoxicity against human NCI-H1975 cells by MTT assay Cytotoxicity against human NCI-H1975 cells by MTT assay	[PMID: 28506750]

Chemical Information

CAS No. 471-71-6
Molecular Weight 433.58
Formula C₂₅H₃₉NO₅
SMILES

C[C@@]12[C@](CC([C@]3([H])[C@]2([H])CC/C([C@@H]3C)=C\C(OCCN(C)C)=O)=O)([H])[C@](C)(CCC1)C(OC)=O
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ha MT, et al. Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of Erythrophleum fordii. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2946-2952. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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