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Cat. No.: HY-146474

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EGFR-IN-54

EGFR-IN-54 (Compound 3c) is a potent EGFR inhibitor with an IC₅₀ of 1.623 µM. EGFR-IN-54 shows cytotoxic activity against cancer cell lines.

For research use only. We do not sell to patients.

CAS No.: 2418549-30-9
Formula: C₁₇H₁₄N₄O₄S₃
Molecular Weight:434.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EGFR-IN-54 Chemical Structure

CAS No.: 2418549-30-9

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR-IN-54 (Compound 3c) is a potent EGFR inhibitor with an IC₅₀ of 1.623 µM. EGFR-IN-54 shows cytotoxic activity against cancer cell lines^[1].

IC₅₀ & Target

EGFR

1.623 μM (IC₅₀)

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	2.53 μM Compound: 3c	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay	[PMID: 32361329]
HepG2	IC₅₀	2.99 μM Compound: 3c	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay	[PMID: 32361329]
MCF7	IC₅₀	11.65 μM Compound: 3c	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay	[PMID: 32361329]
WI-38	IC₅₀	201 μM Compound: 3c	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay	[PMID: 32361329]

Chemical Information

CAS No. 2418549-30-9
Molecular Weight 434.51
Formula C₁₇H₁₄N₄O₄S₃
SMILES

O=S(C1=CC=C(NC(NC2=CC=C(OCO3)C3=C2)=S)C=C1)(NC4=NC=CS4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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