1. PROTAC
  2. Ligand for E3 Ligase
  3. VHL Ligand 8

VHL Ligand 8 

Cat. No.: HY-133045 Purity: 98.02% ee.: 96.40%
Handling Instructions

VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM.

For research use only. We do not sell to patients.

VHL Ligand 8 Chemical Structure

VHL Ligand 8 Chemical Structure

Size Price Stock Quantity
50 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].

IC50 & Target[1]

VHL

 

Molecular Weight

443.49

Formula

C₂₃H₂₉N₃O₆

SMILES

OC(C[[email protected]@H](C1=CC=CC=C1)NC([[email protected]]2N(C([[email protected]](C(C)C)C3=CC(C)=NO3)=O)C[[email protected]](O)C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

VHL Ligand 8VHL Ligand8VHL Ligand-8Ligand for E3 LigaseE3 ligase-recruiting MoietyVHLligandARD-266androgenreceptorInhibitorinhibitorinhibit

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VHL Ligand 8
Cat. No.:
HY-133045
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