Evomonoside
Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 508-93-0
- Formula: C29H44O8
- Molecular Weight:520.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | CC50 |
0.7 μM
Compound: 3, alpha-L-Rhap-Dig
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Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
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[PMID: 24900847] |
| HFF | CC50 |
2 μM
Compound: 3, alpha-L-Rhap-Dig
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Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
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[PMID: 24900847] |
| NCI-H460 | IC50 |
46.7 nM
Compound: 6, alpha-L-rhamnose
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Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
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[PMID: 21643465] |
| NCI-H460 | IC50 |
47.03 nM
Compound: 4, mono-4
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Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
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[PMID: 21660118] |
| NCI-H460 | IC50 |
51.71 nM
Compound: 4, C5'-Me-4
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Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
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[PMID: 21572583] |
| NCI-H460 | IC50 |
52 nM
Compound: 4, C5'-Me-4
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Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
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[PMID: 21572583] |
Chemical Information
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CAS No. 508-93-0
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Molecular Weight 520.65
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Formula C29H44O8
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SMILES
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O)([H])CC3)C
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Evomonoside Related Classifications
HY-W741940 Related Classifications
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