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  7. Evomonoside

Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer.

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Evomonoside

Evomonoside Chemical Structure

CAS No. : 508-93-0

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Description

Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer[1].

Cellular Effect
Cell Line Type Value Description References
HFF CC50
0.7 μM
Compound: 3, alpha-L-Rhap-Dig
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
[PMID: 24900847]
HFF CC50
2 μM
Compound: 3, alpha-L-Rhap-Dig
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
[PMID: 24900847]
NCI-H460 IC50
46.7 nM
Compound: 6, alpha-L-rhamnose
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
[PMID: 21643465]
NCI-H460 IC50
47.03 nM
Compound: 4, mono-4
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21660118]
NCI-H460 IC50
51.71 nM
Compound: 4, C5'-Me-4
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21572583]
NCI-H460 IC50
52 nM
Compound: 4, C5'-Me-4
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21572583]
Molecular Weight

520.65

Formula

C29H44O8
CAS No.
SMILES

O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@@H]([C@@H]([C@H]([C@@H](O6)C)O)O)O)([H])CC3)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Evomonoside Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evomonoside508-93-0Otherscardiac glycosidecytotoxicityLepidium apetalumdigitoxigeninanticancer activityInhibitorinhibitorinhibit

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