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Cat. No.: HY-146366

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Tubulin inhibitor 26

Tubulin inhibitor 26 (compound 3c) is a potent inhibitor of tubulin. Tubulin inhibitor 26 is an indazole derivative compound. Tubulin inhibitor 26 shows noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 arrests tumor cell in G2/M phase and induced cell apoptosis. Tubulin inhibitor 26 suppresses tumor growth in vivo without affecting the mice body weight.

For research use only. We do not sell to patients.

CAS No.: 2379241-70-8
Formula: C₁₇H₁₉N₃O₃
Molecular Weight:313.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tubulin inhibitor 26 Chemical Structure

CAS No.: 2379241-70-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.033 μM Compound: 3c	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HCT-116	GI₅₀	0.015 μM Compound: 3c	Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HepG2	GI₅₀	0.027 μM Compound: 3c	Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HT-29	GI₅₀	0.031 μM Compound: 3c	Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HUVEC	GI₅₀	>25 μM Compound: 3c	Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
SW-620	GI₅₀	0.008 μM Compound: 3c	Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]

Chemical Information

CAS No. 2379241-70-8
Molecular Weight 313.35
Formula C₁₇H₁₉N₃O₃
SMILES

COC1=CC(NC2=NNC3=CC(C)=CC=C32)=CC(OC)=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cui YJ, et al. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo. Eur J Med Chem. 2020;187:111968 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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