Tubulin inhibitor 26

製品番号: HY-146366: Data Sheet 取扱説明書
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Tubulin inhibitor 26 (compound 3c) is a potent inhibitor of tubulin. Tubulin inhibitor 26 is an indazole derivative compound. Tubulin inhibitor 26 shows noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 arrests tumor cell in G2/M phase and induced cell apoptosis. Tubulin inhibitor 26 suppresses tumor growth in vivo without affecting the mice body weight.

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Tubulin inhibitor 26 構造式

CAS 番号 : 2379241-70-8

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.033 μM Compound: 3c	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HCT-116	GI₅₀	0.015 μM Compound: 3c	Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HT-29	GI₅₀	0.031 μM Compound: 3c	Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HUVEC	GI₅₀	> 25 μM Compound: 3c	Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HepG2	GI₅₀	0.027 μM Compound: 3c	Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
SW-620	GI₅₀	0.008 μM Compound: 3c	Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]

分子量

313.35

分子式

C₁₇H₁₉N₃O₃

CAS 番号

2379241-70-8

SMILES

COC1=CC(NC2=NNC3=CC(C)=CC=C32)=CC(OC)=C1OC

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Cui YJ, et al. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo. Eur J Med Chem. 2020;187:111968 [Content Brief]