2. Natural Products
  3. Plants Phenylpropanoids
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  5. Kadsura coccinea (Lem.) A. C. Smith
  6. Angeloylbinankadsurin A

Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC50=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC50=19.9 μM, 21.93 μM).

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Angeloylbinankadsurin A Chemical Structure

Angeloylbinankadsurin A Chemical Structure

CAS No. : 77165-80-1

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Description

Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC50=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC50=19.9 μM, 21.93 μM)[1].

Molecular Weight

484.54

Formula

C27H32O8
CAS No.
SMILES

O=C(/C(C)=C/C)O[C@H]1C2=C(C3=C(C(OC)=C(C=C3C[C@H]([C@H]1C)C)OC)O)C(OC)=C4OCOC4=C2
Structure Classification
Initial Source
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  • Do most proteins show cross-species activity?

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Keywords:

Angeloylbinankadsurin A77165-80-1OthersCytotoxicityHeilaohuKadsura coccineaLignanRheumatoid arthritisTujia ethnomedicineInhibitorinhibitorinhibit

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