New Lignans from roots of Kadsura coccinea

  • Fitoterapia. 2019 Nov:139:104368. doi: 10.1016/j.fitote.2019.104368.
Yupei Yang  1 ,  Yongbei Liu  1 ,  Muhammad Daniyal  1 ,  Huanghe Yu  1 ,  Qingling Xie  1 ,  Bin Li  1 ,  Yuqing Jian  2 ,  Rongyong Man  3 ,  Sanhu Wang  3 ,  Xiaoling Zhou  4 ,  Bin Liu  5 ,  Wei Wang  6
Affiliations
  • 1. TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China.
  • 2. TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China. Electronic address: [email protected].
  • 3. Clinic Experimental Research Center, the first people's hospital of Huaihua, Huihua 418000, People's Republic of China.
  • 4. Department of Gastroenterology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou 545001, People's Republic of China.
  • 5. Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha 410125, People's Republic of China.
  • 6. TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, People's Republic of China. Electronic address: [email protected].
PMID: 31629046 DOI: 10.1016/j.fitote.2019.104368
Abstract

Four new dibenzocyclooctadiene Lignans, named heilaohusus A-D (1-4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6-12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8-12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human Cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC50 values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC50 values of 14.57 and 11.70 μM, respectively.

Keywords
Cytotoxicity; Heilaohu; Kadsura coccinea; Lignan; Rheumatoid arthritis; Tujia ethnomedicine.
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