SQS-IN-1
SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer.
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- CAS No.: 2306302-57-6
- Formule: C24H27BrN2O5
- Masse moléculaire:503.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
In Vitro
SQS-IN-1 (Compound 2) (0.1 nM-100 μM, 24-72 h) inhibits various lung cancer cell lines proliferation including LLCOVA cells, NSCLC cell lines (H1299 and H358) and B16 melanoma cells and with TC50s of 3.21 nM, 1.6 μM, 0.55 μM and 0.21 μM at 72 h[1].
SQS-IN-1 (10 and 0.1 μM, 24 h) induces G0/G1 phase arrest in A549 cells and arrested DNA replication in LLC-OVA cells[1].
SQS-IN-1 (0.1 μM, 24 h) induces LLC-OVA cells apoptosis and effectively inhibits the metastasis ability of cancer cells[1].
SQS-IN-1 (0-10 μM) causes mitochondrial hyperpolarization in a dose-dependent manner in LLC-OVA cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and LLC-OVA cells
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Concentration:10 μM (A549) and 0.1 μM (LLC-OVA)
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Incubation Time:24 h
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Result:Significantly reduced the proportion of cells in the S phase and the G2 phase, resulting in the accumulation of cells in the G0/G1 phase in A549 cells.
Inhibited DNA replication and the cell cycle progression in LLC-OVA.
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Cell Line:LLC-OVA cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Significantly increased the percentage of cells in the early apoptotic stage.
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Cell Line:LLC-OVA cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Reduced the wound closure rate of LLC-OVA cells by approximately 23%.
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Cell Line:LLC-OVA cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Reduced the invasive ability of LLC-OVA cells by 25%.
- Scratch/Wound-Healing Migration Assay
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Cell migration
- Neural Crest/Neuronal Cell Migration Explant Assay
- Protocol for Cell Cycle
- Cell Viability Determination by MTT Colorimetric Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- PCNA Immunodetection Proliferation Assay
- Flow cytometric DNA-content cell-cycle staining
- Zigmond Chamber Chemotaxis Assay
- Under-Agarose Cell Migration Assay
- Transwell/Boyden Chamber Migration Assay
- Apoptosis Solutions
- 3D Collagen/Hydrogel Matrix Migration Assay
- Cell invasion
- Cell-Exclusion Zone Migration Assay
- Dunn/Insall Chamber Chemotaxis Assay
Chemical Information
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CAS No. 2306302-57-6
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Masse moléculaire 503.39
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Formule C24H27BrN2O5
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SMILES
CN1CCOC(C2=CC=C(C3=CC=C(C=CC=C4)C4=C3)C=C2)(OCCCO[N+]([O-])=O)C1.Br
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SQS-IN-1 Related Classifications
HY-178158 Related Classifications
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