SQS-IN-1
SQS-IN-1 is a squalene synthase (SQS) inhibitor. SQS-IN-1 exhibits potent and broad-spectrum anti-proliferative effects on both mouse and human lung cancer cell lines. SQS-IN-1 inhibits DNA replication and the cell cycle, causing mitochondrial hyperpolarization and inducing cell apoptosis. SQS-IN-1 inhibits cell migration and invasion. SQS-IN-1 can be used to the study of lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 2306302-57-6
- Formula: C24H27BrN2O5
- Molecular Weight:503.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SQS-IN-1 (Compound 2) (0.1 nM-100 μM, 24-72 h) inhibits various lung cancer cell lines proliferation including LLCOVA cells, NSCLC cell lines (H1299 and H358) and B16 melanoma cells and with TC50s of 3.21 nM, 1.6 μM, 0.55 μM and 0.21 μM at 72 h[1].
SQS-IN-1 (10 and 0.1 μM, 24 h) induces G0/G1 phase arrest in A549 cells and arrested DNA replication in LLC-OVA cells[1].
SQS-IN-1 (0.1 μM, 24 h) induces LLC-OVA cells apoptosis and effectively inhibits the metastasis ability of cancer cells[1].
SQS-IN-1 (0-10 μM) causes mitochondrial hyperpolarization in a dose-dependent manner in LLC-OVA cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and LLC-OVA cells
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Concentration:10 μM (A549) and 0.1 μM (LLC-OVA)
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Incubation Time:24 h
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Result:Significantly reduced the proportion of cells in the S phase and the G2 phase, resulting in the accumulation of cells in the G0/G1 phase in A549 cells.
Inhibited DNA replication and the cell cycle progression in LLC-OVA.
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Cell Line:LLC-OVA cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Significantly increased the percentage of cells in the early apoptotic stage.
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Cell Line:LLC-OVA cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Reduced the wound closure rate of LLC-OVA cells by approximately 23%.
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Cell Line:LLC-OVA cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Reduced the invasive ability of LLC-OVA cells by 25%.
Chemical Information
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CAS No. 2306302-57-6
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Molecular Weight 503.39
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Formula C24H27BrN2O5
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SMILES
CN1CCOC(C2=CC=C(C3=CC=C(C=CC=C4)C4=C3)C=C2)(OCCCO[N+]([O-])=O)C1.Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SQS-IN-1 Related Classifications
HY-178158 Related Classifications
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