EGFR T790M/VEGFR-2-IN-1
EGFR T790M/VEGFR-2-IN-1 (Compound 6) is a dual EGFR T790M mutant (IC50=0.26 μM) and VEGFR-2 (IC50=0.95 μM) inhibitor. EGFR T790M/VEGFR-2-IN-1 blocks tumor cell proliferation and angiogenesis signaling pathways. EGFR T790M/VEGFR-2-IN-1 exhibits potent cytotoxicity against multiple cancer cell lines (HCT116, MCF-7, HepG2, A549; IC50=5.35-9.90 μM). EGFR T790M/VEGFR-2-IN-1 is promising for research of non-small cell lung cancer and solid tumors.
For research use only. We do not sell to patients.
- Formula: C18H15N11O3S
- Molecular Weight:465.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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EGFRT790M 0.26 μM (IC50) |
VEGFR2 0.95 μM (IC50) |
Chemical Information
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Molecular Weight 465.45
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Formula C18H15N11O3S
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SMILES
O=S(C1=CC=C(/N=N/C2=C3N=C(N)C(C#N)=C(C4=CC=CO4)N3N=C2N)C=C1)(/N=C(N)\N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR T790M/VEGFR-2-IN-1 Related Classifications
HY-175297 Related Classifications
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