2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. QN523

QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.

For research use only. We do not sell to patients.

QN523 Chemical Structure

QN523 Chemical Structure

CAS No. : 878581-60-3

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5 mg USD 140 In-stock
10 mg USD 220 In-stock
25 mg USD 440 In-stock
50 mg USD 690 In-stock
100 mg USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

QN523 Related Antibodies

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Description

QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer[1].

In Vitro

QN523 (72 h) has cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines[1].
QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QN523 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MIA PaCa-2 cells
Concentration: 0.1 and 0.5 μM
Incubation Time: 24 and 48 hours
Result: Delayed for pancreatic cancer cells to enter the G2-M phase because of accumulation of cells in the S phase.

Apoptosis Analysis[1]

Cell Line: MIA PaCa-2 cells
Concentration: 0.1 and 0.5 μM
Incubation Time: 24 and 48 hours
Result: Increased the number of apoptotic cell in time- and dose-dependent manner.
In Vivo

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)
Dosage: 10 and 20 mg/kg
Administration: Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg)
Result: Delayed growth of the tumors, and no systemic toxicity.
Molecular Weight

250.26

Formula

C14H10N4O
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

O=C(C1=NC=CN=C1)NC2=CC=CC3=CC=CN=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 16.67 mg/mL (66.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9958 mL 19.9792 mL 39.9584 mL
5 mM 0.7992 mL 3.9958 mL 7.9917 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9958 mL 19.9792 mL 39.9584 mL 99.8961 mL
5 mM 0.7992 mL 3.9958 mL 7.9917 mL 19.9792 mL
10 mM 0.3996 mL 1.9979 mL 3.9958 mL 9.9896 mL
15 mM 0.2664 mL 1.3319 mL 2.6639 mL 6.6597 mL
20 mM 0.1998 mL 0.9990 mL 1.9979 mL 4.9948 mL
25 mM 0.1598 mL 0.7992 mL 1.5983 mL 3.9958 mL
30 mM 0.1332 mL 0.6660 mL 1.3319 mL 3.3299 mL
40 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4974 mL
50 mM 0.0799 mL 0.3996 mL 0.7992 mL 1.9979 mL
60 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6649 mL
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QN523 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QN523878581-60-3QN 523QN-523ApoptosisAutophagyanticancerdrug-like propertycytotoxicitycancer cellInhibitorinhibitorinhibit

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