Erufosine
Erufosine is an inhibitor of PI3K/Akt and Ras/Raf/MAPK signaling pathways. Erufosine inhibits the activity of breast cancer cell lines MCF-7 and MDA-MB 231 (IC50: 40.95/40.8 μM). Erufosine reduces the phosphorylation of PI3K (p85), Akt (PKB), and cRaf. Erufosine can be used in the study of breast cancer and myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 202867-33-2
- Formula: C28H58NO4P
- Molecular Weight:503.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
28 μM
Compound: Erufosine
|
Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
|
[PMID: 36827952] |
| THP-1 | CC50 |
2 μM
Compound: Erufosine
|
Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
|
[PMID: 36827952] |
Chemical Information
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CAS No. 202867-33-2
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Molecular Weight 503.74
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Formula C28H58NO4P
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SMILES
CCCCCCCC/C=C\CCCCCCCCCCCCOP(OCCC[N+](C)(C)C)([O-])=O
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Synonyms
ErPC3; Erucylphosphohomocholine
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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