Tubulin-IN-56

Tubulin-IN-56 (Compound 1b) (12-48 h) increases the number of M-phase arrested cells and the apoptotic fraction in colorectal cancer cells (LS180, HCT116, SW620, LoVo) over time^[1].
Tubulin-IN-56 shows antiproliferative activity against LS180, HCT116, SW620 and LoVo cells, with IC₅₀ values of 279 nM, 102 nM, 132 nM and 45 nM, respectively^[1].
Tubulin-IN-56 (3 μM, 80 min) alters microtubule polymerization rates in colon cancer cells (HCT116 and LoVo cells)^[1].
Tubulin-IN-56 significantly downregulates βIII-tubulin and upregulates βIVa-tubulin in SW620, HCT116, and LoVo cells^[1].
Tubulin-IN-56 (8 h) inhibits the invasiveness and reduces MMP-7 secretion in SW620, HCT116, and LoVo cells Tubulin-IN-56 decreases the cytosolic level of integrin-linked kinase (ILK) in LoVo cells^[1].
Tubulin-IN-56 (1 μM, 4 h) elevates intracellular ROS levels in LS180, SW620, and LoVo cells^[1].
Tubulin-IN-56 (72 h) reduces the growth of LoVo cell spheroids in 3D culture^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.