2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. CC-M-1

CC-M-1 is a potent and selective PI3K/mTOR inhibitor. CC-M-1 inhibits PI3Kα/β/γ/δ and mTOR with IC50 values of 0.68, 1.02, 1.03, 8.03, and 15 nM, respectively. CC-M-1 inhibits the proliferation of colorectal cancer cell lines, including HCT-116 (IC50 = 0.38 μM) and HT-29 (IC50 = 1.70 μM). CC-M-1 can be used for colorectal cancer (CRC) research.

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CC-M-1

CC-M-1 Chemical Structure

CAS No. : 3079943-00-0

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CC-M-1 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Description

CC-M-1 is a potent and selective PI3K/mTOR inhibitor. CC-M-1 inhibits PI3Kα/β/γ/δ and mTOR with IC50 values of 0.68, 1.02, 1.03, 8.03, and 15 nM, respectively. CC-M-1 inhibits the proliferation of colorectal cancer cell lines, including HCT-116 (IC50 = 0.38 μM) and HT-29 (IC50 = 1.70 μM). CC-M-1 can be used for colorectal cancer (CRC) research[1].

IC50 & Target[1]

PI3Kα

0.68 nM (IC50)

PI3Kβ

1.02 nM (IC50)

PI3Kγ

1.03 nM (IC50)

PI3Kδ

8.03 nM (IC50)

mTOR

15 nM (IC50)

Molecular Weight

625.65

Formula

C28H29F2N9O4S
CAS No.
SMILES

COC1=C(C=C(C=N1)C2=NN3C(C4=CN(N=N4)CCCN5CCCC(C5)O)=CN=C3C=C2)NS(=O)(C6=C(C=C(C=C6)F)F)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CC-M-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC-M-13079943-00-0PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinPI3K/mTORcolorectal cancerHCT-116HT-29Inhibitorinhibitorinhibit

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