1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR

AMG-337 

Cat. No.: HY-18696 Purity: 99.19%
Handling Instructions

AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays.

For research use only. We do not sell to patients.
AMG-337 Chemical Structure

AMG-337 Chemical Structure

CAS No. : 1173699-31-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
5 mg USD 120 In-stock
10 mg USD 204 In-stock
25 mg USD 348 In-stock
50 mg USD 588 In-stock
100 mg USD 900 In-stock
200 mg USD 1440 In-stock
500 mg   Get quote  
1 g   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. IC50 value: < 5nM [1] Target: MET in vitro: AMG-337 demonstrates exquisite selectivity for MET when profiled against a diverse panel of over 400 protein and lipid kinases in a competitive binding assay. In cellular assays, AMG 337 inhibits HGF-dependent MET phosphorylation with an IC50 of < 10 nM. [1] AMG 337 is a selective inhibitor of Met, which inhibits multiple mechanisms of Met activation. [2] in vivo: AMG-337 demonstrates robust activity in MET-dependent cancer models. Oral administration of AMG 337 results in robust dose-dependent anti-tumor efficacy in MET amplified gastric cancer xenograft models, with inhibition of tumor growth consistent with the pharmacodynamic modulation of MET signaling.[1]

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1577 mL 10.7884 mL 21.5768 mL
5 mM 0.4315 mL 2.1577 mL 4.3154 mL
10 mM 0.2158 mL 1.0788 mL 2.1577 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

463.46

Formula

C₂₃H₂₂FN₇O₃

CAS No.

1173699-31-4

SMILES

O=C1C2=C(N=CC(OCCOC)=C2)C=CN1[[email protected]@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.19%

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Product Name:
AMG-337
Cat. No.:
HY-18696
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