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Art. -Nr.: HY-15990

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CH5164840

CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (K_d = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC₅₀ = 0.15 μM, NCI-N87 IC₅₀ = 0.066 μM). CH5164840 (16) is orally active (t_1/2 = 2.64 h) with potent antitumor efficacy.

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CAS. Nr.: 1052645-73-4
Formel: C₁₉H₂₃N₅O₂S
Molecular Weight:385.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CH5164840 Chemical Structure

CAS. Nr.: 1052645-73-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.15 μM Compound: 16, CH5164840	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 22192591]
NCI-N87	IC₅₀	0.066 μM Compound: 16, CH5164840	Antiproliferative activity against human NCI-N87 cells overexpressing Her-2 Antiproliferative activity against human NCI-N87 cells overexpressing Her-2	[PMID: 22192591]

Chemical Information

CAS. Nr. 1052645-73-4
Molecular Weight 385.48
Formel C₁₉H₂₃N₅O₂S
SMILES

O=C(NCCCNC1=O)CCSC2=CC(C3=CC1=C(C)C=C3C)=NC(N)=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Atsushi Suda, et al. Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1136-41. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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CH5164840

Alle HSP Isoform-spezifische Produkte anzeigen