1052645-73-4
1052645-73-4
Chemical Structure
CH5164840
- CAS No.: 1052645-73-4
- Formula:C19H23N5O2S
- Molecular Weight:385.48
IUPAC Name: 12-amino-24,26-dimethyl-12-thia-4,8-diaza-1(4,6)-pyrimidina-2(1,3)-benzenacyclododecaphane-3,9-dione
InChIKey: OMFBVBRFVYLRQT-UHFFFAOYSA-N
SMILES: O=C(NCCCNC1=O)CCSC2=CC(C3=CC1=C(C)C=C3C)=NC(N)=N2
Biological Activity: CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (Kd = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC50 = 0.15 μM, NCI-N87 IC50 = 0.066 μM). CH5164840 (16) is orally active (t1/2 = 2.64 h) with potent antitumor efficacy[1].
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CH5164840 | CH5164840 (16) shows high binding affinity for N-terminal Hsp90a (Kd = 0.52 nM) and strong anti-proliferative activity against human cancer cell lines (HCT116 IC50 = 0.15 μM, NCI-N87 IC50 = 0.066 μM). CH5164840 (16) is orally active (t1/2 = 2.64 h) with potent antitumor efficacy. | |||||||||||||||||||||
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References
Keywords
