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Cat. No.: HY-155413

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Antiproliferative agent-43

Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase.

For research use only. We do not sell to patients.

CAS No.: 3034239-44-3
Formula: C₄₅H₅₇NO₆S₂
Molecular Weight:772.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antiproliferative agent-43 Chemical Structure

CAS No.: 3034239-44-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase^[1].

In Vitro

Antiproliferative agent-43 (0, 1.23, 2.45, 2.90 μM, 48 h) induces G1 phase cell cycle arrest in K562 cells, accompanied by abnormal nuclear morphology ^[1].
Antiproliferative agent-43 (0, 1.23, 2.45 , 2.90 μM, 48 h) apoptosis induces by mitochondrial pathway in K562 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

K562
Concentration:

0, 1.23, 2.45 , 2.90 μM
Incubation Time:

48h
Result:

Induced G1 phase cell cycle arrest in the K562 cell line.

Apoptosis Analysis^[1]

Cell Line:

K562
Concentration:

0, 1.23, 2.45 , 2.90 μM
Incubation Time:

48h
Result:

The apoptotic cells induced by antiproliferative agent-43 increased from 6.35% in the negative control to 13.36, 37.99, and 64.94%, with a concentration-dependent manner.

Chemical Information

CAS No. 3034239-44-3
Molecular Weight 772.07
Formula C₄₅H₅₇NO₆S₂
SMILES

COC1=CC=C(C[C@H](N(CC2)C)[C@](C=C3OC)([H])[C@@]42CC3=O)C4=C1OCCCCOC(CCCCC(SCC5=CC=CC=C5)CCSCC6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gao X, et al. Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway. Bioorg Med Chem Lett. 2023 Nov 7;97:129545. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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