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NSC-57969

NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines.

For research use only. We do not sell to patients.

CAS No.: 6632-09-3
Formula: C₁₅H₁₈N₂O
Molecular Weight:242.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NSC-57969 Chemical Structure

CAS No.: 6632-09-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BT-483	GI₅₀	26.9 μM Compound: 7	Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium Growth inhibition of human BT-483 cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium	[PMID: 19748786]
HeLa	GI₅₀	0.35 μM Compound: 7	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM CuCl2	[PMID: 19748786]
HeLa	GI₅₀	0.58 μM Compound: 7	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10 uM CuCl2	[PMID: 19748786]
HeLa	GI₅₀	12.9 μM Compound: 7	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 100 uM ZnCl2	[PMID: 19748786]
HeLa	GI₅₀	14.5 μM Compound: 7	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 10% FBS supplemented DMEM medium	[PMID: 19748786]
HeLa	GI₅₀	3 μM Compound: 7	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 1 uM CuCl2	[PMID: 19748786]
HeLa	GI₅₀	8.5 μM Compound: 7	Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2 Growth inhibition of human HeLa cells after 48 hrs by MTT assay in presence of 50 uM ZnCl2	[PMID: 19748786]
MES-SA	IC₅₀	4.18 μM Compound: 3	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay	[PMID: 35613553]
MES-SA	IC₅₀	5.21 μM Compound: 3	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay	[PMID: 35613553]
MES-SA/Dx5	IC₅₀	0.85 μM Compound: 3	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs by PrestoBlue reagent based cell viability assay	[PMID: 35613553]
MES-SA/Dx5	IC₅₀	2.69 μM Compound: 3	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 72 hrs in presence of P-gp inhibitor Tariquidar by PrestoBlue reagent based cell viability assay	[PMID: 35613553]
MRC5	IC₅₀	>4.17 μM Compound: DNDI1416985	DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells.	10.6019/CHEMBL2094269

Chemical Information

CAS No. 6632-09-3
Molecular Weight 242.32
Formula C₁₅H₁₈N₂O
SMILES

OC1=C2N=CC=CC2=CC=C1CN3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. András Füredi, et al. Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line-Specific Effects from P-Glycoprotein-Induced Toxicity. Mol Cancer Ther. 2017 Jan;16(1):45-56. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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