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Cat. No.: HY-175221

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WHN-11

WHN-11 is an amino-Artemisinin (HY-B0094) derivative with anti-cancer activity against various cancer cell lines. WHN-11 deprives the cell of ATP, activates autophagy, and causes subsequent cell death by apoptosis. WHN-11 alters cellular protein homeostasis pathways to induce mitochondrial fission and dysfunction. WHN-11's anti-cancer activity is independent of substantive ROS production. WHN-11 can be used for the study of triple-negative breast cancer (TNBC).

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화학식: C₂₇H₃₆F₃N₃O₅
분자량:539.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

WHN-11 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	15 μM Compound: 9i	Cytotoxicity against human A375 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human A375 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]
A549	IC₅₀	21.1 μM Compound: 9i	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]
L02	IC₅₀	4 μM Compound: 9i	Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]
MCF7	IC₅₀	2.7 μM Compound: 9i	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]
MDA-MB-231	IC₅₀	5.8 μM Compound: 9i	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]
SH-SY5Y	IC₅₀	3.2 μM Compound: 9i	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]
U-87MG ATCC	IC₅₀	15.2 μM Compound: 9i	Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29789258]

In Vitro

WHN-11 exhibits significant cytotoxicity against HCC1937 (IC₅₀ = 0.74 μM), HCC70 (0.19 μM) and MDA-MB-231 TNBC cell lines (0.5 μM), HeLa cervical carcinoma (0.84 μM), U87 glioblastoma (6.57 μM), 501mel melanoma (0.2 μM) and HCT116 colon cancer cell lines (0.44 μM)^[1].
WHN-11 inhibits tumoursphere formation in the HCC1937 TNBC cell line^[1].
WHN-11 (5-80 μM, 9 days) significantly decreases colony formation of HCC1937 cells in a dose-dependent manner^[1].
WHN-11 (1-50 μM, 24 h) promotes the cleavage of caspase-3 in a dose-dependent fashion rather than RARP-1^[1].
WHN-11 does not alter ROS and NQO1 mRNA levels in HCC1937 cells^[1].
WHN-11 perturbs protein homeostasis, including ubiquitination and proteasomal degradation in HCC1937 cells^[1].
WHN-11 (0.1-40 μM, 1-16 h) activates apoptotic and autophagic signaling pathways in HCC1937 cells^[1].
WHN-11 (1-50 μM) induces an indication of mitochondrial stress and dysfunction of HCC1937 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HCC1937 cells
Concentration:

0.1, 10 and 50 μM
Incubation Time:

1, 4 and 16 h
Result:

Induced both autophagy (as indicated by LC3B-I lipidation) and apoptosis (as indicated by caspase-3 cleavage) only after a prolonged exposure of 16 h.

Chemical Information

분자량 539.59
화학식 C₂₇H₃₆F₃N₃O₅
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@H]1N5CCN(CC5)C(NC6=CC=C(C=C6)C(F)(F)F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kajewole D, et al. The novel amino-artemisinin derivative WHN-11 disrupts mitochondria and protein homeostasis, and induces autophagy and apoptosis in cancer cells. Sci Rep. 2025 Jul 1;15(1):21604. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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