TOPOI/PARP-1-IN-2
TOPOI/PARP-1-IN-2 (compound 6c) is a dual PARP-1 and topoisomerase 1 (TOPO-1) inhibitor with IC50s of 32.2 nM and 46.2 nM, respectively. TOPOI/PARP-1-IN-2 shows a selectivity for PARP-1 over PARP-2. TOPOI/PARP-1-IN-2 disrupts the cell cycle at the S phase and induces apoptosis in NCI-60 cancer cell lines.
For research use only. We do not sell to patients.
- Formula: C16H11ClN4O2S
- Molecular Weight:358.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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PARP-1 32.2 nM (IC50) |
Top1 46.2 nM (IC50) |
PARP-2 2844 nM (IC50) |
Chemical Information
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Molecular Weight 358.80
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Formula C16H11ClN4O2S
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SMILES
S=C(N(NC(C1=C2C=CC=C1)=O)C2=O)N/N=C/C3=CC=CC=C3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TOPOI/PARP-1-IN-2 Related Classifications
HY-169299 Related Classifications
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