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LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway.

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LM2I Chemical Structure

LM2I Chemical Structure

CAS No. : 2055494-50-1

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LM2I Related Antibodies

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Description

LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway[1].

IC50 & Target

Argininosuccinate synthetase (ASS1)[1]
In Vitro

LM2I (0µM~10µM, 48h) shows strong inhibitory effect in CRC cell lines[1].
LM2I (2µM, 15d) inhibits the EGFR pathway in colorectal cancer cells[1].
LM2I inhibits colorectal cancer cells via EGFR[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LM2I Related Antibodies

Cell Viability Assay[1]

Cell Line: CRC cell（HT29, SW480, SW620, HCT116, LoVo, RKO, and DLD1)
Concentration: 0µM,1.25µM,2.5µM,3.75µM,5.00µM,6.25µM,7.5µM,8.75µM,10µM
Incubation Time: 48h
Result: Inhibited the viability of HT29, SW480, SW620, HCT116, LoVo, RKO, and DLD1 cells.

Cell Proliferation Assay[1]

Cell Line: HT29 and SW480 cells
Concentration: 0.75µM,1µM
Incubation Time: 14d
Result: Had almost no effect on EGFR-KO cells.

Western Blot Analysis[1]

Cell Line: HT29, SW480, SW620, HCT116, LoVo, RKO, DLD1 cell
Concentration: 2µM
Incubation Time: 0~15d
Result: EGFR protein levels were higher than control group.Time-dependently inhibited the protein levels of EGFR and significantly reduced relative to phosphorylation.
In Vivo

LM2I (2.5 mg/kg/day, ip, every other day for 28 days) inhibits tumor growth in nude mice xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic BALB/c nude mice xenograft model(injected subcutaneously into the flank region with HT29 cell)[1].
Dosage: 2.5 mg/kg/day
Administration: Intraperitoneal injection,every other day for 28 days
Result: The tumor weight was significantly lower than that of the control group, and the tumor cell density was lower.
Molecular Weight

860.13

Formula

C47H77N3O11
CAS No.
SMILES

O=C(C1=C[C@]2([H])[C@](C=C[C@@]3([H])[C@@]2([H])C[C@H](O[C@@H]4O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]4OC)C3)([H])[C@]1([H])C5)[C@H](C)[C@@H](O[C@@H]6O[C@H](C)[C@@H](N(CC(O)CN7CCNCC7)C)CC6)CCC[C@H](CC)OC5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LM2I Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM2I2055494-50-1OthersCRC cell linesBALB/c female miceColorectal cancer.Inhibitorinhibitorinhibit

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