EGFR-IN-52
EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 454436-75-0
- Formula: C19H18N4O3S
- Molecular Weight:382.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
|
EGFR 0.358 μM (IC50) |
EGFRL858R 86.02 μM (IC50) |
EGFRT790M 432.67 μM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
3.16 μM
Compound: 4
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| HepG2 | IC50 |
3.79 μM
Compound: 4
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| MCF7 | IC50 |
16.96 μM
Compound: 4
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| WI-38 | IC50 |
176 μM
Compound: 4
|
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
Chemical Information
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CAS No. 454436-75-0
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Molecular Weight 382.44
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Formula C19H18N4O3S
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SMILES
CC1=C(C(N(N1C)C2=CC=CC=C2)=O)NC(NC3=CC=C4OCOC4=C3)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)