EGFR-IN-52
EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 454436-75-0
- 分子式: C19H18N4O3S
- 分子量:382.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
EGFR アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
|
EGFR 0.358 μM (IC50) |
EGFRL858R 86.02 μM (IC50) |
EGFRT790M 432.67 μM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
3.16 μM
Compound: 4
|
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| HepG2 | IC50 |
3.79 μM
Compound: 4
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| MCF7 | IC50 |
16.96 μM
Compound: 4
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
| WI-38 | IC50 |
176 μM
Compound: 4
|
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 32361329] |
化学情報
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CAS 番号 454436-75-0
-
分子量 382.44
-
分子式 C19H18N4O3S
-
SMILES
CC1=C(C(N(N1C)C2=CC=CC=C2)=O)NC(NC3=CC=C4OCOC4=C3)=S
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)