454436-75-0
454436-75-0
Chemical Structure
EGFR-IN-52
- CAS No.: 454436-75-0
- Formula:C19H18N4O3S
- Molecular Weight:382.44
IUPAC Name: 1-(benzo[d][1,3]dioxol-5-yl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)thiourea
InChIKey: ZNMSKFVKBVCPAJ-UHFFFAOYSA-N
SMILES: CC1=C(C(N(N1C)C2=CC=CC=C2)=O)NC(NC3=CC=C4OCOC4=C3)=S
Biological Activity: EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
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EGFR-IN-52 | EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis. | |||||||||||||||||||||
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