Anticancer peptoid 1  (Synonyms: Peptoid 1)

Anticancer peptoid 1 (Peptoid 1) is a peptoid with antitumor activity. Anticancer peptoid 1 exerts cytotoxicity primarily via plasma membrane damage. Anticancer peptoid 1 exerts cytotoxicity against a broad range of cancer cell lines, including those with multidrug resistance. Anticancer peptoid 1 inhibits tumor growth in a human breast cancer xenotransplantation mouse model without noticeable acute adverse effects. Anticancer peptoid 1 can be used for the research of cancer, such as breast cancer, and prostate cancer^[1].

Anticancer peptoid 1 (72 h) potently induces cytotoxicity in MCF-7, LNCaP, OVCAR-3, MRC-5, and primary dermal fibroblast cells with LC₅₀ values of 5, 5, 6, 8, and 8 μM respectively after 72 h treatment^[1].
Anticancer peptoid 1 (0-50 μM; 72 h) potently induces cytotoxicity in both MCF-7 and multidrug-resistant MCF-7/TxT50 cells, overcoming multidrug resistance^[1].
Anticancer peptoid 1 (50 μM; 5-60 min) induces rapid plasma membrane damage in MCF-7 cells, with 50 μM causing ~50% LDH leakage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer peptoid 1 (1 mg/kg; mammary fat pad injection; three times per week; 12 weeks) significantly inhibits tumor growth in a human breast cancer orthotopic xenograft mouse model with no observed acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1819.32

C₁₀₄H₁₃₉N₁₇O₁₂

620948-14-3

({NLys}-{Nspe}-{Nspe})4-NH2

({NLys}-{Nspe}-{Nspe})4-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huang W, et al. Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity. PLoS One. 2014;9(2):e90397. Published 2014 Feb 28.  [Content Brief]